Lipopolysaccharide promotes early endometrial-peritoneal interactions in a mouse model of endometriosis

Kaoru Keyama, Takeshi Kato, Yuri Kadota, Otgontsetseg Erdenebayar, Kana Kasai, Takako Kawakita, Anna Tani, Sumika Matsui, Takeshi Iwasa, Kanako Yoshida, Masahiko Maegawa, Akira Kuwahara, Toshiya Matsuzaki, Minoru Irahara
The journal of medical investigation : JMI · 2019 · vol. 66(1.2) , pp. 70–74 · doi:10.2152/jmi.66.70 · PMID:31064958 · W2941652024
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

Lipopolysaccharide promotes the development of early endometriotic lesions in mice by increasing pro-inflammatory cytokines and chemokines in the peritoneal cavity.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This study examined how lipopolysaccharide (LPS) affects early endometriosis development and the associated cytokine/chemokine production in the murine peritoneal cavity. Endometriotic lesions were induced in adult C57BL/6J female mice by intraperitoneal injection of endometrial fragments with blood, or with blood plus LPS, and lesion development was assessed on day 7 by gross and microscopic evaluation; time-dependent TNF-α, IL-6, and CXCL2/MIP-2 secretion in peritoneal lavage was measured by ELISA. LPS exposure significantly increased the area of endometriotic lesions compared with control, and proinflammatory mediators showed rapid kinetics, with TNF-α and IL-6 peaking within 2 hours and MIP-2 reaching maximum on day 1. The paper’s caveat is that it focuses specifically on early timepoints (day 7 lesion assessment and short-term cytokine kinetics) in a mouse model. This paper is centrally about endometriosis — it tests LPS-driven early endometrial–peritoneal interactions and inflammatory mediator production in a mouse endometriosis model.

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Abstract

PURPOSE: The aims of this study were to clarify the effects of lipopolysaccharide (LPS) on the early development of endometriosis and on the production of cytokines and chemokines in the murine peritoneal cavity. METHODS: Endometriotic lesions were induced in C57BL/6J adult female mice by intraperitoneal injection of endometrial fragments plus blood or endometrial fragments plus blood with LPS. On day 7, endometriotic lesions were assessed by gross and microscopic evaluations. Time-dependent changes in the secretion of TNF-α,IL-6,and CXCL2/MIP-2 in peritoneal lavage fluid after the intraperitoneal injection of LPS (50 µg/body) were measured by their respective enzyme-linked immunosorbent assays. RESULTS: ).The levels of TNF-α and IL-6 peaked within 2 hours and the level of MIP-2 reached a maximum on day 1 after the injection of LPS. CONCLUSIONS: LPS promotes development of the early stages of murine endometriotic lesions. J. Med. Invest. 66 : 70-74, February, 2019.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Lipopolysaccharides Peritoneum Animals Chemokine CXCL2 Chemokine CXCL2 Cytokines Cytokines Disease Models, Animal Endometriosis Endometriosis Endometrium Female Lipopolysaccharides Mice Mice, Inbred C57BL Peritoneum

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