Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis

Kana Kasai, Kasai K, Kato T, Takeshi Kato, Kadota Y, Yuri Kadota, Otgontsetseg Erdenebayar, Keyama K, Kaoru Keyama, Kawakita T, Takako Kawakita, Yoshida K, Kanako Yoshida, Akira Kuwahara, Kuwahara A, Toshiya Matsuzaki, Matsuzaki T, Minoru Irahara, Irahara M
The journal of medical investigation : JMI · 2019 · vol. 66(1.2) , pp. 123–127 · doi:10.2152/jmi.66.123 · PMID:31064924 · W2941439294
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Intraperitoneal administration of activin A in a mouse model significantly increased endometriotic lesion size and inflammatory cytokine levels compared to controls.

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The paper studied whether intraperitoneal administration of activin A affects the development of endometriotic lesions in a mouse model. C57BL/6J 7–8-week-old recipient mice received intraperitoneal inoculation with donor mouse endometrial tissue and blood to induce endometriosis, and activin A (400 μg intraperitoneally for 5 days) was compared with a control condition. Activin A–treated mice had significantly larger maximum lesion diameters and greater total lesion area, and their washed ascites showed higher IL-6 and TNF-α levels. This study supports a role for activin in promoting lesion development and inflammation, and this paper is centrally about endometriosis—intraperitoneal activin A administration to promote endometriotic lesion development in mice.

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Abstract

PURPOSE : This study aimed to investigate the effect of intraperitoneal administration of activin on the occurrence of endometriosis using a mouse model of endometriosis. METHODS : A mouse model of endometriosis was prepared by intraperitoneally administering endometrial tissue and blood collected from donor mice to C57BL/6J 7-8- week-old recipient mice. A total of 400 μg of activin A was intraperitoneally administered to model mice in the activin group for 5 days. Intraperitoneal endometriotic lesions were confirmed macroscopically and IL-6 and TNF-α levels in washed ascites were measured by ELISA. RESULTS : Endometriotic lesions were observed in all mice. In the activin group, the maximum diameter of endometriotic lesions was significantly larger than that in control group (4.7?1.3 vs 2.9?0.9 mm, p?0.01). The total area of the lesion was also significantly higher in the activin group than in the control group (21.1?9.9 vs 8.8?5.4 mm2,p?0.01). Furthermore, IL-6 and TNF-α levels in ascites were significantly higher in the activin group than in the control group (IL-6 : 85.8?15.3 vs 75.1?19.3 pg/ml, p?0.05 ; TNF-α : 629.8?15.4 vs 605.9?11.4 pg/ml, p?0.05). CONCLUSION : Activin promotes occurrence of endometriosis. Inflammatory cytokines are also elevated by activin administration,suggesting that they may contribute to progression of endometriosis J. Med. Invest. 66 : 123-127, February, 2019
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Intraperitoneal administration of activin A promotes development of endometriotic lesions in a mouse model of endometriosis 2019 Volume 66 Issue 1.2 Pages 123-127 Details Abstract PURPOSE : This study aimed to investigate the effect of intraperitoneal administration of activin on the occurrence of endometriosis using a mouse model of endometriosis. METHODS : A mouse model of endometriosis was prepared by intraperitoneally administering endometrial tissue and blood collected from donor mice to C57BL/6J 7-8- week-old recipient mice. A total of 400 μg of activin A was intraperitoneally administered to model mice in the activin group for 5 days. Intraperitoneal endometriotic lesions were confirmed macroscopically and IL-6 and TNF-α levels in washed ascites were measured by ELISA. RESULTS : Endometriotic lesions were observed in all mice. In the activin group, the maximum diameter of endometriotic lesions was significantly larger than that in control group (4.7?1.3 vs 2.9?0.9 mm, p?0.01). The total area of the lesion was also significantly higher in the activin group than in the control group (21.1?9.9 vs 8.8?5.4 mm2,p?0.01). Furthermore, IL-6 and TNF-α levels in ascites were significantly higher in the activin group than in the control group (IL-6 : 85.8?15.3 vs 75.1?19.3 pg/ml, p?0.05 ; TNF-α : 629.8?15.4 vs 605.9?11.4 pg/ml, p?0.05). CONCLUSION : Activin promotes occurrence of endometriosis. Inflammatory cytokines are also elevated by activin administration,suggesting that they may contribute to progression of endometriosis J. Med. Invest. 66 : 123-127, February, 2019 © 2019 by The University of Tokushima Faculty of Medicine Favorites & Alerts Recently viewed articles

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Condition tags

endometriosis

MeSH descriptors

Activins Disease Models, Animal Endometriosis Activins Activins Animals Endometriosis Endometriosis Female Injections, Intraperitoneal Interleukin-6 Interleukin-6 Mice Mice, Inbred C57BL Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha

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