Activin-A is induced by interleukin-1β and tumor necrosis factor-α and enhances the mRNA expression of interleukin-6 and protease-activated receptor-2 and proliferation of stromal cells from endometrioma

Osamu Yoshino, Yoshino O, Izumi G, Gentaro Izumi, Jia Shi, Shi J, Yutaka Osuga, Osuga Y, Yasushi Hirota, Tetsuya Hirata, Miyuki Harada, Osamu Nishii, Nishii O, Kaori Koga, Taketani Y, Yuji Taketani
Fertility and sterility · 2011 · vol. 96(1) , pp. 118–121 · doi:10.1016/j.fertnstert.2011.05.006 · PMID:21640344 · W2065702178
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Interleukin-1β and tumor necrosis factor-α induce Activin-A, which in turn increases interleukin-6 and protease-activated receptor-2 mRNA expression and stromal cell proliferation in endometrioma.

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Abstract

ObjectiveTo examine the regulation and the function of activin-A in stromal cells derived from endometrioma.DesignMolecular studies.SettingUniversity research laboratory.Patient(s)Endometrioma stromal cells (EoSC) were obtained from 28 patients with ovarian endometrioma undergoing laparoscopy.Intervention(s)EoSC were cultured with inflammatory stimuli or recombinant activin-A, followed by RNA extraction.Main outcome measure(s)Activin mRNA expression was evaluated by real-time reverse transcription-polymerase chain reaction (RT-PCR), and activin-A concentration of supernatant of cultured EoSC was evaluated by ELISA. Also, the effect of activin-A on EoSC was evaluated with real-time RT-PCR and cell proliferation assay.Result(s)Inflammatory stimuli, interleukin (IL) -1β, and tumor necrosis factor (TNF) -α induced inhibin/activin-βA subunit mRNA and activin-A protein expression in EoSC. Additionally, activin-A enhanced EoSC proliferation and increased the expression of IL-6 and protease-activated receptor (PAR)-2 mRNA.Conclusion(s)An in vitro study revealed that activin-A, which is induced by IL-1β or TNF-α, might promote endometriosis by stimulating IL-6 and PAR-2 mRNA expression and increasing the proliferation of EoSC.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Activins Endometriosis Interleukin-1beta Interleukin-6 Receptor, PAR-2 Tumor Necrosis Factor-alpha Activins Activins Cell Proliferation Cell Proliferation Cells, Cultured Endometriosis Endometriosis Female Gene Expression Regulation Humans Interleukin-1beta Interleukin-6 Interleukin-6 Receptor, PAR-2

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