Activin A, Activin Receptor Type II, Nodal, and Cripto mRNA Are Expressed by Eutopic and Ectopic Endometrium in Women With Ovarian Endometriosis

Paulo B Torres, Pasquale Florio, Letizia Galleri, Fernando M Reis, Lavínia E. Borges, Lavinia E Borges, Felice Petraglia
Reproductive sciences (Thousand Oaks, Calif.) · 2009 · vol. 16(8) , pp. 727–733 · doi:10.1177/1933719109334967 · PMID:19386982 · W2066769798
article OA: closed CC0 ⤵ 11 in-corpus citations
Limited metadata. Only one source feed has indexed this record so far — no abstract, full text, or open-access copy is available through Endo Lab. The publisher's page (linked below) is the canonical location for the actual content. If you have institutional access, use "Find at my library".
View at publisher → View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Activin A and cripto mRNA expression were altered in the eutopic and ectopic endometrium of women with endometriosis compared to controls.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study measured mRNA levels of activin A, activin receptor type II (ActRII), nodal, and cripto in eutopic endometrium from 15 women with ovarian endometrioma and 15 healthy controls, and additionally in ectopic endometrium from the patients, using real-time PCR with attention to menstrual cycle phase. Activin A mRNA was significantly higher in patients’ eutopic endometrium than in controls, with the increase reported in both proliferative and secretory phases, whereas ActRII and nodal mRNA were similar between patients and controls; cripto mRNA was markedly lower in both proliferative-phase eutopic endometrium and ectopic endometrium from patients compared with healthy controls’ eutopic endometrium. A key caveat is the small sample size (n=15 per group for controls and patients) and reliance on mRNA expression rather than protein signaling activity. Relevance to endometriosis: the authors directly compare gene expression in eutopic and ectopic endometrium from women with ovarian endometrioma and conclude that altered activin system expression may be involved in endometrial changes in endometriosis. This paper is centrally about endometriosis — it characterizes activin pathway and cripto/nodal-related gene expression differences between eutopic and ectopic endometrium in ovarian endometrioma patients.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Activin Receptors, Type II Activins Choristoma Endometriosis Endometrium Epidermal Growth Factor Membrane Glycoproteins Neoplasm Proteins Nodal Protein Ovarian Diseases Activin Receptors, Type II Activins Adult Case-Control Studies Endometriosis Epidermal Growth Factor Female GPI-Linked Proteins Humans Intercellular Signaling Peptides and Proteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (46)

Cited by (11)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:14:11.755070+00:00
License: CC0 · commercial use OK