Eutopic endometrium from women with endometriosis does not exhibit neurotrophic properties

Maria Luisa Barcena, Maria Luisa Barcena de Arellano, Barcena de Arellano ML, Julia T. Arnold, Arnold J, Julia Arnold, Sacher F, Frank Sacher, Matthias Blöchle, Blöchle M, Staube M, Magdalena Staube, Julia Bartley, Bartley J, Giuseppe F Vercellino, Giuseppe Filiberto Vercellino, Vercellino GF, Vito Chiàntera, Vito Chiantera, Schneider A, Achim Schneider, Sylvia Mechsner
Journal of neuroimmunology · 2012 · vol. 249(1-2) , pp. 49–55 · doi:10.1016/j.jneuroim.2012.04.020 · PMID:22633194 · W2065053683
article OA: closed CC0 ⤵ 20 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated whether eutopic endometrium from women with endometriosis possesses neurotrophic properties, finding that it does not.

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Abstract

The role of neurotrophins in eutopic endometrium from endometriosis-patients was investigated in a prospective study using immunofluorescence-staining, Western blot and a neuronal growth assay. The nerve growth factor is expressed in primary endometrial cell culture from women with and without endometriosis. Western blot analysis of endometrial biopsies or uterine fluid from patients with and without endometriosis shows no difference in the neurotrophin expression. We could not find a difference between patients with and without endometriosis with regards to the neurite outgrowth of sensory ganglia when treated with conditioned cultured medium or uterine fluid. This result refutes the assumed neurotrophic properties of eutopic endometrium of patients with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Nerve Growth Factor Neurites Uterine Diseases Adult Blotting, Western Culture Media, Conditioned Culture Media, Conditioned Culture Media, Conditioned Endometriosis Female Fluorescent Antibody Technique Humans Middle Aged Nerve Growth Factor Neurites Uterine Diseases Young Adult

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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