Julia T. Arnold

BACKGROUND: Recent studies demonstrated the potential involvement of nerve fibres in the chronic inflammatory process of endometriosis. We aimed to characterize nerve fibres in the proximal and distal areas of the peritoneal endometriotic l…

To investigate the neurotrophic properties of endometriosis, as well as the involvement of neurotrophic factors in the development of chronic pelvic pain in patients with endometriosis, we performed a prospective clinical study. The presenc…

The role of neurotrophins in eutopic endometrium from endometriosis-patients was investigated in a prospective study using immunofluorescence-staining, Western blot and a neuronal growth assay. The nerve growth factor is expressed in primar…

OBJECTIVES: An imbalance in the ratio of sensory to sympathetic nerve fibre (NF) density in peritoneal endometriotic lesions (pEL) has recently been demonstrated and leads to the assumption that this preponderance of the sensory pro-inflamm…

To investigate the involvement of neurotrophins and nerve fibres in the pathogenesis of adenomyosis, we performed a retrospective, clinical study. Hysterectomy specimens from 40 patients with histologically proven adenomyosis and from 20 pa…

Objectives: An imbalance in the ratio of sensory to sympathetic nerve fibre (NF) density in peritoneal endometriotic lesions (pEL) has recently been demonstrated and leads to the assumption that this preponderance of the sensory pro-inflamm…

To investigate possible mechanisms of pain pathophysiology in patients with peritoneal endometriosis, a clinical study on sensory and sympathetic nerve fibre sprouting in endometriosis was performed. Peritoneal lesions (n=40) and healthy pe…

To investigate the role of the nerve growth factor (NGF) in the development of dysmenorrhea/pelvic pain in patients with endometriosis, we performed a prospective, clinical, blind study. Peritoneal fluids (PFs) were obtained from patients w…

Einleitung: Das eutope Endometrium von Frauen mit Endometriose (EM) weist im Vergleich zu nicht an EM erkrankten Frauen vielfältige Unterschiede auf. Ein neues Kriterium in der Unterscheidung des Endometriums von Frauen mit und ohne EM sind…

Introduction: The development of endometriosis (EM) associated pain seems to be strongly influenced by the incidence of nerve fibers (NF) in close contact to the endometriotic lesions. NF as well as neurotrophins (NT) are found closely to p…

Question: The nervous system (NS) has an influence on the pathogenesis of chronic inflammatory autoimmune diseases (AID). The sympathetic NS exerts an anti-inflammatory effect while the sensory NS promotes inflammatory changes, through a st…

To investigate the role of the nerve growth factor (NGF) in the endometriosis-associated innervation in the development of endometriosis-associated symptoms, 41 peritoneal fluid samples (PF) from patients with surgically and histologically …