Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine fibroids

Xinmei Zhang, Zhang X, Bangchun Lu, Lu B, Xiufeng Huang, Hong Xu, Xu H, Zhou C, Caiyun Zhou, Lin J, Jun Lin
Fertility and sterility · 2009 · vol. 92(5) , pp. 1799–1801 · doi:10.1016/j.fertnstert.2009.05.016 · PMID:19535047 · W2079497712
article OA: bronze CC0 ⤵ 92 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated and characterized endometrial nerve fiber density and morphology in women diagnosed with endometriosis, adenomyosis, and uterine fibroids.

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Abstract

To determine whether nerve fibers in the functional layer endometrium are caused by an endometriosis itself or a common symptom of pain, endometrial tissues from 30 women with endometriosis, 40 women with adenomyosis, 41 women with uterine fibroids, and 47 endometriosis women with adenomyosis were stained immunohistochemically using the highly specific polyclonal rabbit antiprotein gene product 9.5 (PGP9.5) and monoclonal mouse antineurofilament protein. We demonstrated PGP9.5-immunoactive nerve fibers in the functional layer of endometrium in women with pain symptoms, but not in women without pain symptoms, whether the women had endometriosis, adenomyosis, uterine fibroids, or endometriosis with adenomyosis, suggesting a role of PGP9.5-immunoactive nerve fibers in the functional layer of the endometrium playing in pain generation in these disorders.

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Condition tags

endometriosischronic_pelvic_painadenomyosis

MeSH descriptors

Endometriosis Endometrium Leiomyoma Nerve Fibers Peritoneal Diseases Uterine Neoplasms Adult Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Leiomyoma Leiomyoma Middle Aged Nerve Fibers Nerve Fibers Pelvic Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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