β-Adrenoreceptors types 1 and 2 in the diagnosis of pain syndrome in patientswith various forms of adenomyosis

L.V. Adamyan, A.D. Sokolov, A.S. Arakelyan, Алина Бадлаева, A.V. Asaturova
In: Russian Journal of Human Reproduction · 2025 · vol. 31(1) , pp. 35 · doi:10.17116/repro20253101135 · W4408362714
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study found increased expression of β1- and β2-adrenergic receptors in adenomyosis tissues, directly correlating with pain severity in patients.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

The paper studied immunohistochemical expression of β1- and β2-adrenergic receptors (ADRB1/ADRB2) in tissue from adenomyosis lesions in reproductive-age women, comparing diffuse (n=30) and nodular (n=30) disease with a group of 30 patients who had pain syndrome without adenomyosis on instrumental diagnostics. Using preoperative high-field MRI to create 3D models of the uterus and surgical sampling (with histology and immunohistochemistry), the authors assessed pain severity by a visual analog scale (VAS) before and after surgery and compared clinical features between groups. A key limitation is that the provided text does not include the actual immunohistochemical results for ADRB1/ADRB2, so the reported main finding cannot be determined from the excerpt alone. Relevance to endometriosis: adenomyosis is the primary focus, and the paper frames its neurogenic/sympathetic receptor mechanisms (including prior reports of ADRB2 in adenomyosis) within broader pelvic pain pathways that are conceptually overlapping with endometriosis, but the excerpt does not explicitly discuss endometriosis.

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Abstract

Objective. Analysis of immunohistochemical expression of β1- and β2-adrenergic receptors (ADRB1 and ADRB2) in adenomyotic tissues in reproductive-age patients. Material and methods. The study included histological preparations and paraffin blocks from 30 patients with diffuse adenomyosis, 30 patients with nodular adenomyosis and 30 patients from the comparison group. Histological and immunohistochemical studies of excised adenomyosis tissue were performed in the 1st pathological anatomy department of the Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology of the Ministry of Health of the Russian Federation. Results. The study showed increased expression of β1- and β2-adrenergic receptors in adenomyosis foci compared to the control group, while a direct relationship was established when assessing the relationship between ADRB2 expression and ADRB1 expression. A direct relationship was also established between the severity of pain syndrome (assessed by the VAS scale) in patients with various forms of adenomyosis and the expression of β1- and β2-adrenergic receptors in the tissue of adenomyosis. Conclusion. The data obtained by us allow us to objectify the severity of pain syndrome in patients with various forms of adenomyosis, since the level of expression of β1- and β2-adrenergic receptors positively correlates with the severity of pain syndrome. These findings make it possible to optimize the tactics of drug treatment of patients with adenomyosis and clarify the pathogenesis of pain syndrome in adenomyosis.

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Outcome instruments

VAS-pain

Condition tags

adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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