Increased immunoreactivity to SLIT/ROBO1 and its correlation with severity of dysmenorrhea in adenomyosis

Nie J, Jichan Nie, Liu X, Xishi Liu, Zheng Y, Yu Zheng, Geng JG, Jian-Guo Geng, Sun-Wei Guo, Sun‐Wei Guo, Guo SW
Fertility and sterility · 2010 · vol. 95(3) , pp. 1164–1167 · doi:10.1016/j.fertnstert.2010.09.027 · PMID:20970134 · W2083185642
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This study investigated increased immunoreactivity to SLIT/ROBO1 and its correlation with the severity of dysmenorrhea in patients diagnosed with adenomyosis.

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Abstract

Compared with normal endometrium, SLIT expression was statistically significantly higher in ectopic endometrium from women with adenomyosis, while roundabout 1 (ROBO1) immunoreactivity and microvessel density (MVD) level were statistically significantly higher in both eutopic and ectopic endometrium than normal endometrium. Both SLIT immunoreactivity in ectopic endometrium and MVD in eutopic endometrium were positively correlated with the severity of dysmenorrhea and found to be significant predicators for dysmenorrhea severity in women with adenomyosis.

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Condition tags

dysmenorrheaendometriosisadenomyosis

MeSH descriptors

Dysmenorrhea Endometriosis Nerve Tissue Proteins Receptors, Immunologic Severity of Illness Index Biomarkers Biomarkers Dysmenorrhea Endometriosis Female Humans Immunohistochemistry Nerve Tissue Proteins Predictive Value of Tests Receptors, Immunologic Roundabout Proteins

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (28)

Cited by (24)

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