Expression of angiogenic factors in extrapelvic endometriosis

Masaaki Deguchi, M Deguchi, Osamu Ishiko, O Ishiko, T Sumi, Toshiyuki Sumi, H Yoshida, Hiroyuki Yoshida, Kumio Yamamoto, K Yamamoto, Sachio Ogita, S Ogita
Oncology reports · 2001 · vol. 8(6) , pp. 1317–9 · doi:10.3892/or.8.6.1317 · PMID:11605057 · W2037784582
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Extrapelvic and pelvic endometriotic lesions showed differential expression of VEGF and COX-2, with inguinal tumors exhibiting higher immunoreactivity than ovarian tumors.

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The study investigated the expression of the angiogenic factors vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) in pelvic versus extrapelvic endometriotic lesions using immunohistochemistry. The authors reported different expression patterns across lesion sites: VEGF immunoreactivity localized mainly to the cytoplasm of adenocytes in inguinal tumors, with no detectable VEGF in ovarian tumors, and COX-2 showed similar findings. A major caveat is that the brief report provides mainly descriptive immunohistochemical results without deeper mechanistic or quantitative analysis. This paper is centrally about endometriosis — specifically the expression of VEGF and COX-2 in extrapelvic endometriotic lesions.

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Abstract

The expression of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) were immunohistochemically examined in both pelvic and extrapelvic endometriotic lesions. Different expressions of VEGF and COX-2 were observed in both lesions. VEGF immunoreactivity was distributed mainly in the cytoplasm of the adenocytes in inguinal tumors, but was not seen in ovarian tumors. COX-2 showed the same findings. These results suggest that angiogenesis may be involved in the pathogenesis of extrapelvic endometriosis.
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Print ISSN: 1021-335X Online ISSN: 1791-2431 International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease. International Journal of Oncology is an international journal devoted to oncology research and cancer treatment. Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery. Oncology Reports is an international journal devoted to fundamental and applied research in Oncology. Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine. Oncology Letters is an international journal devoted to Experimental and Clinical Oncology. Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology. International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis. Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology. Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition. Publishes open-access research on using epigenetics to advance understanding and treatment of human disease. An International Open Access Journal Devoted to General Medicine. Article - Authors: - Pages: 1317-1319|Published online on: November 1, 2001https://doi.org/10.3892/or.8.6.1317 - Expand metrics + The expression of vascular endothelial growth factor (VEGF) and cyclooxygenase-2 (COX-2) were immunohistochemically examined in both pelvic and extrapelvic endometriotic lesions. Different expressions of VEGF and COX-2 were observed in both lesions. VEGF immunoreactivity was distributed mainly in the cytoplasm of the adenocytes in inguinal tumors, but was not seen in ovarian tumors. COX-2 showed the same findings. These results suggest that angiogenesis may be involved in the pathogenesis of extrapelvic endometriosis. Copy and paste a formatted citation Spandidos Publications style Deguchi M, Ishiko O, Sumi T, Yoshida H, Yamamoto K and Ogita S: Expression of angiogenic factors in extrapelvic endometriosis. Oncol Rep 8: 1317-1319, 2001. APA Deguchi, M., Ishiko, O., Sumi, T., Yoshida, H., Yamamoto, K., & Ogita, S. (2001). Expression of angiogenic factors in extrapelvic endometriosis. Oncology Reports, 8, 1317-1319. https://doi.org/10.3892/or.8.6.1317 MLA Deguchi, M., Ishiko, O., Sumi, T., Yoshida, H., Yamamoto, K., Ogita, S."Expression of angiogenic factors in extrapelvic endometriosis". Oncology Reports 8.6 (2001): 1317-1319. Chicago Deguchi, M., Ishiko, O., Sumi, T., Yoshida, H., Yamamoto, K., Ogita, S."Expression of angiogenic factors in extrapelvic endometriosis". Oncology Reports 8, no. 6 (2001): 1317-1319. https://doi.org/10.3892/or.8.6.1317

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Condition tags

endometriosis

MeSH descriptors

Abdominal Neoplasms Abdominal Neoplasms Endometriosis Endometriosis Endothelial Growth Factors Isoenzymes Lymphokines Ovarian Cysts Prostaglandin-Endoperoxide Synthases Abdominal Neoplasms Abdominal Neoplasms Adult Cyclooxygenase 2 Endometriosis Endometriosis Endothelial Growth Factors Female Humans Immunohistochemistry Inguinal Canal

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