Association of epidermal growth factor receptor gene polymorphisms with advanced endometriosis in a Korean population

Lee GH, Gyoung Hoon Lee, Choi YM, Young Min Choi, Kim JM, Jong Mee Kim, Jae Jun Shin, Jung Gu Kim, Kim JG, Moon SY, Shin Yong Moon
European journal of obstetrics, gynecology, and reproductive biology · 2012 · vol. 164(2) , pp. 196–199 · doi:10.1016/j.ejogrb.2012.06.004 · PMID:22770632 · W2028047905
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This study investigated the link between epidermal growth factor receptor gene polymorphisms and advanced endometriosis in a Korean population.

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Abstract

ObjectivesTo determine if specific single nucleotide polymorphisms (SNPs) in the Epidermal Growth Factor Receptor (EGFR) gene were meaningful markers for the risk of advanced stage endometriosis in a Korean population.Study designCase-control study in a collective of 299 women with endometriosis and 285 controls. Three polymorphisms (151904 A>T [T628T] on exon 16 [rs 17337023], 162093 G>A [Q787Q] on exon 20 [rs 10251977], and 181946 C>T [D994D] on exon 25 [rs 2293347]) were assessed by a Minor Groove Binder (MGB) primer/probe Taqman assay. In-silico haplotypes were deduced using the Haploview (version 3.32) software package.ResultsThere were no statistically significant differences in the genotype or haplotype frequencies of the three EGFR polymorphisms between subjects with endometriosis versus the control group. Even when the endometriosis cases were subdivided into stage III and IV based on the ASRM criteria, no statistically significant differences in genotype distribution or haplotype frequencies were observed between the three groups.ConclusionsOur results suggest that the 151904 A>T, 162093 G>A, and 181946 C>T polymorphisms in the EGFR gene are not associated with advanced stage endometriosis in a Korean population. Our results are in agreement with the results reported by Inagaki et al.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis ErbB Receptors Polymorphism, Single Nucleotide Adolescent Adult Alleles Case-Control Studies Computational Biology Endometriosis Endometriosis Endometriosis Endometriosis ErbB Receptors ErbB Receptors Exons Female Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Hospitals, University

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