Dysmenorrhea: Risk Factors in Women with Endometriosis
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⤵ 17 in-corpus citations
Abstract
Although it is generally accepted that endometriosis is responsible for dysmenorrhea, as well as other symptoms such as infertility, the precise relationship between the severity of dysmenorrhea and various characteristics of disease, such as stage and the type or site of endometriotic lesions, has been elusive and often a matter of heated debate, owing largely to conflicting reports. Here we review factors that are reported to be associated with dysmenorrhea in endometriosis. We also demonstrate, through a real example, that different statistical models employed in data analyses may yield somewhat different sets of risk factors, and the difference may not be always resolved within the same data set. In addition, we make the point that despite the best-fitting models, there may still be a sizable portion of variation in the severity of dysmenorrhea that can not be explained completely by the identified risk factors, suggesting that factors other than those of surgical findings or patient characteristics may also be responsible for dysmenorrhea severity. We review some possible factors that may also be responsible for the risk and severity of dysmenorrhea. Finally, we expose areas in need of further research.
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Cited by (17)
- Pathophysiology of Endometriosis: Insights from Immunohistochemical Analysis of Ectopic and Eutopic Tissues 2025
- Identification of lesional attributes of dysmenorrhea severity and the serum antimüllerian hormone levels in women with ovarian endometriomas 2022
- Characteristics of Endometriosis Patients in RSUP Dr. Kariadi Semarang in 2018 2022
- The effectiveness of therapy for endometriosis-associated pelvic pain resistant to surgical treatment 2021
- Mesothelial Cells Participate in Endometriosis Fibrogenesis Through Platelet-Induced Mesothelial-Mesenchymal Transition 2020
- Evidence in Support for the Progressive Nature of Ovarian Endometriomas 2020
- Platelets induce endothelial–mesenchymal transition and subsequent fibrogenesis in endometriosis 2020
- Plasma High Mobility Group Box 1 (HMGB1), Osteopontin (OPN), and Hyaluronic Acid (HA) as Admissible Biomarkers for Endometriosis 2019
- Anti-platelet therapy holds promises in treating adenomyosis: experimental evidence 2016
- Constitutive and tumor necrosis factor-α-induced activation of nuclear factor-κB in adenomyosis and its inhibition by andrographolide 2013
- Clinical profiles of 710 premenopausal women with adenomyosis who underwent hysterectomy 2013
- Evaluation of the Impact of Endometriotic Lesions on Patient'S Pelvic Pain Symptoms 2010
- Elevated immunoreactivity to tissue factor and its association with dysmenorrhea severity and the amount of menses in adenomyosis 2010
- Evaluation of the impact of endometriotic lesions on patient's pelvic pain symptoms 2010
- Increased immunoreactivity to SLIT/ROBO1 and its correlation with severity of dysmenorrhea in adenomyosis 2010
- A call for more transparency of registered clinical trials on endometriosis 2009
- Emerging drugs for endometriosis 2008
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