Expression of transforming growth factor β1 in nerve fibers is related to dysmenorrhea and laparoscopic appearance of endometriotic implants

Tamburro S, Stefano Tamburro, S. Tamburro, Michel Canis, Albuisson E, Eliane Albuisson, Éliane Albuisson, Pierre Dechelotte, Dechelotte P, Pierre Déchelotte, Claude Darcha, Darcha C, Mage G, G. Mage, Gérard Mage
Fertility and Sterility · 2003 · vol. 80(5) , pp. 1131–1136 · doi:10.1016/s0015-0282(03)01182-8 · PMID:14607563 · W2146589244
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This study investigated the presence of transforming growth factor β1 in nerve fibers of women with and without dysmenorrhea, finding a correlation with endometriotic implants seen during laparoscopy.

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Abstract

ObjectiveTo quantify the expression of transforming growth factor beta1 in nerve fibers in endometriotic lesions and to correlate it with dysmenorrhea and appearance of endometriotic implants.DesignProspective comparative study.SettingUniversity hospital.Patient(s)Peritoneal endometriotic specimens obtained from 35 patients diagnosed with endometriosis were compared with biopsies of normal peritoneum from 10 patients without endometriosis.Intervention(s)Endometriosis-associated dysmenorrhea for each patient was evaluated before surgery using a 10-point visual analog scale, which was followed by a laparoscopic staging of the patient's endometriosis.Main outcome measure(s)Immunohistochemical analysis of the peritoneal endometriotic specimens evaluated the maximal intensity of staining (INTMMAX) of TGFbeta1, defined as higher staining intensity found within a selected structure.Result(s)When the nerve fibers of endometriotic lesions were compared with those of normal peritoneum, statistically significant differences were found in the INTMMAX of TGFbeta1. Greater TGFbeta1 INTMMAX was found in red lesions and deep endometriotic foci than in black lesions and normal peritoneum. A statistically significant relationship was found between the TGFbeta1 INTMMAX score and dysmenorrhea; a relationship also was found to the color of the lesions.Conclusion(s)The physical appearance of endometriotic implants and the severity of dysmenorrhea appear to be related to the expression of TGFbeta1 in nerve fibers.

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Condition tags

dysmenorrheaendometriosischronic_pelvic_pain

MeSH descriptors

Dysmenorrhea Endometriosis Endometriosis Hysteroscopy Nerve Fibers Transforming Growth Factor beta Adult Biopsy Color Dysmenorrhea Dysmenorrhea Endometriosis Endometrium Endometrium Endometrium Endometrium Female Humans Immunohistochemistry Immunohistochemistry

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