Endometrial nerve fibers in women with endometriosis, adenomyosis, and uterine

Xinmei Zhang, Bangchun Lu, Xiufeng Huang, Hong Xu, Caiyun Zhou, Jun Lin
2009 · W2739648909
article OA: closed CC0 Metadata only
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Endometrial nerve fibers, identified by PGP9.5 staining, were present in women experiencing pain, regardless of their specific gynecological condition.

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Abstract

fibroids To determine whether nerve fibers in the functional layer endometrium are caused by an endometriosis itself or a common symptom of pain, endometrial tissues from 30 women with endometriosis, 40 women with adenomyosis, 41 women with uterine fibroids, and 47 endometriosis women with adenomyosis were stained immunohistochemically using the highly specific polyclonal rabbit antiprotein gene product 9.5 (PGP9.5) and monoclonal mouse antineurofilament protein. We demonstrated PGP9.5-immunoactive nerve fibers in the functional layer of endometrium in women with pain symptoms, but not in women without pain symptoms, whether the women had endometriosis, adenomyosis, uterine fibroids, or endometriosis with adenomyosis, suggesting a role of PGP9.5-immunoactive nerve fibers in the functional layer of the endometrium playing in pain generation in these disorders. (Fertil Steril� 2009;92:1799‐1801. � 2009 by American Society for Reproductive Medicine.) Although increasing evidence has demonstrated nerve fibers in the functionallayer ofendometrium in women with endometriosis (1‐ 3), it is still a controversy whether nerve fibers in the functional layer of the endometrium are caused by an endometriosis itself or a common symptom of pain in this disorder (4). Most recently, wefoundthat proteingene product(PGP) 9.5-immunoactivenerve fibers in the functional layer of the endometrium were only present in women with pain symptoms, but not in women without pain symptoms, whether the women had adenomyosis or uterine fibroids (5). Because adenomyosis or uterine fibroids, like endometriosis, is an estrogen-dependent disease, we hypothesized that PGP 9.5-immunoactive nerve fibers in the functional layer of the endometrium are caused by a common symptom of pain rather than by an endometriosis disease itself.

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Condition tags

endometriosisadenomyosis

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