Nerve Fibers and Histopathology of Endometriosis-Harboring Peritoneum
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This paper examined the nerve fibers and histopathology of peritoneal tissue from women with endometriosis to understand the underlying tissue changes.
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Abstract
Study objectiveTo evaluate the presence of nerve fibers and histopathology of normal peritoneum and endometriosis-harboring peritoneum.DesignProspective, nonrandomized study (Canadian Task Force classification II-1).SettingUniversity hospital.MaterialsPeritoneal specimen from 40 women with laparoscopic findings of endometriosis (24 confirmed histopathologically, group H, 16 diagnosed by laparoscopy, group L) and from 9 women with no endometriosis (controls).InterventionHistopathologic examination of peritoneal specimens with nerve fibers identified by immunocytochemistry staining with an antibody to neurofilament.Measurements and main resultsNo differences in mean nerve score were seen among the three groups. Degrees of lymphocytic infiltration and mesothelial hyperplasia were higher in group H than in the other two groups (p <0.01 and <0.05, respectively). The degree of lymphocytic infiltration was significantly higher in group L than in the control group (p <0.05). There were no differences in all measurements between women in group H who experienced chronic pelvic pain and those who did not.ConclusionThe presence of nerve fibers in peritoneum is not related to endometriosis. Endometriosis-harboring peritoneum contains more lymphocytic infiltration than normal peritoneum. (J Am Assoc Gynecol Laparosc 8(1):95-98, 2001)
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- Microanatomy and function of the eutopic endometrium in women with endometriosis 2008
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- Different types of small nerve fibers in eutopic endometrium and myometrium in women with endometriosis 2007
- Nerve fibres in peritoneal endometriosis 2006
- Quality of sex life in women with endometriosis and deep dyspareunia 2005
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