A Proposed Platform for Phenotyping Endometriosis-Associated Pain: Unifying Peripheral and Central Pain Mechanisms

Paul J. Yong, Christina Williams, Mohamed A. Bedaiwy, Catherine Allaire
In: Current Obstetrics and Gynecology Reports · 2020 · vol. 9(3) , pp. 89–97 · doi:10.1007/s13669-020-00288-8 · W3031200642
article OA: closed CC0 ⤵ 7 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

This review identifies peripheral and central factors modulating endometriosis-associated pain and proposes a four-type classification based on these mechanisms.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This paper is a review proposing a platform for phenotyping endometriosis-associated pain by unifying peripheral and central pain mechanisms. It synthesizes evidence that pain development and persistence reflect an interplay between peripheral factors (lesion anatomy such as superficial/deep/ovarian features, local inflammation, neurogenesis and peripheral nerve sensitization, uterine factors including eutopic neuroinflammation with concurrent adenomyosis, and adjacent pelvic pain generators) and central factors (central nervous system/cross-organ sensitization, systemic pain conditions like fibromyalgia, and psychosocial comorbidities). The authors propose four endometriosis pain sub-types—type I (lesion-related), type II (comorbidity-driven), type III (central), and type IV (mixed)—and explicitly note that the classification requires further study and validation. This paper is centrally about endometriosis — it proposes a peripheral-to-central phenotyping and classification framework for endometriosis-associated pain.

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endometriosis

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last seen: 2026-06-10T17:14:06.276822+00:00
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