Mysteries of endometriosis pain: Chien‐Tien Hsu Memorial Lecture 2009

Ian S Fraser
Journal of Obstetrics and Gynaecology Research · 2010 · vol. 36(1) , pp. 1–10 · doi:10.1111/j.1447-0756.2010.01181.x · PMID:20178521 · W2136142999
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Abstract

The more that one looks at the condition endometriosis, the more one realises that it is a unique and complex condition exhibiting a bizarre range of deviations from normal endometrial and myometrial physiology, and presenting with a challenging range of pain-related symptoms. The changing nature of the pain is not well defined, and the molecular mechanisms leading to pain generation are far from clear. Recent research has begun to reveal some of these links between expression of unusual molecules in the eutopic endometrium and ectopic lesions, microanatomical changes in the pelvic nervous system, neuronal dysfunction and the later development of neuropathic pain. A better understanding of these mechanisms will undoubtedly lead to improved use of current medical and surgical treatments, and to the development of novel treatments in the future.

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Condition tags

mesh:D004715mesh:D017699endometriosis

MeSH descriptors

Endometriosis Endometrium Pelvic Pain Contraceptives, Oral, Combined Contraceptives, Oral, Combined Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Humans Myometrium Myometrium Myometrium Nerve Fibers Nerve Growth Factor Nerve Growth Factor Pelvic Pain

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