Chronic pelvic pain in women: role of the nervous system

Wayne R. Gillett, David S. Jones
In: Expert Review of Obstetrics & Gynecology · 2009 · vol. 4(2) , pp. 149–163 · doi:10.1586/17474108.4.2.149 · W2135404229
article OA: closed CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review correlates knowledge on nervous system mechanisms, including peripheral and central sensitization, that contribute to chronic pelvic pain in women, highlighting a lack of evidence-based management.

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Abstract

There is increasing recognition that mechanisms in the nervous system common to other persistent pain conditions and inflammation of neurogenic origin play a major role in chronic pelvic pain. For either somatic or visceral pain, an understanding of the processes of peripheral and central sensitization mechanisms, common to both acute and persistent pain, should help explain difficult pain conditions and open new therapeutic options. This review aims to correlate knowledge regarding persistent pain causation and pain conditions in gynecology. Although there is emerging evidence about the pathophysiology and management of persistent pain, there is still a dearth of evidence-based practice for chronic pelvic pain in women.

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