Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons

Thomas D'Hooghe, Thomas D’Hooghe, Thomas M D'Hooghe, Sophie Debrock
Human reproduction update · 2002 · vol. 8(1) , pp. 84–88 · doi:10.1093/humupd/8.1.84 · PMID:11866244 · W2143537649
review OA: bronze CC0 ⤵ 185 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review critically assesses the evidence in women and baboons for retrograde menstruation as a key factor in endometriosis pathogenesis, highlighting the need for further understanding of menstrual events in the peritoneal environment.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The aim of this review was to assess critically the importance of the frequency, quantity and quality of retrograde menstruation and its relationship to peritoneal inflammation. The basis was the current evidence in women and in baboons supporting the Sampson hypothesis that retrograde menstruation is a key factor in the pathogenesis of endometriosis. It is not proven that retrograde menstruation is a universal phenomenon occurring similarly in women with and without endometriosis. A more thorough understanding of the physiological, cytological and immunological events in peritoneal fluid, peritoneum, endometrium and uterus during menstruation in women with and without endometriosis is critical in order to understand the pathogenesis of this enigmatic disease.

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Menstruation Disturbances Peritonitis Animals Disease Models, Animal Endometriosis Female Humans Menstruation Disturbances Menstruation Disturbances Papio Peritonitis Prevalence

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (45)

Cited by (50)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-04T00:00:01.174412+00:00
pubmed
last seen: 2026-05-13T22:13:13.417725+00:00
License: CC0 · commercial use OK