The roles and functions of macrophages in endometriosis

Xue Jiao; Miaomiao Ji; Sun‐Wei Guo; Guoyun Wang

doi:10.1016/b978-0-12-820661-4.00007-8

The roles and functions of macrophages in endometriosis

Xue Jiao, Miaomiao Ji, Sun‐Wei Guo, Guoyun Wang

In: Immunology of Endometriosis · 2021 · pp. 133–151 · doi:10.1016/b978-0-12-820661-4.00007-8 · W4200320372

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review explores the diverse roles and functions of macrophages, particularly their subtypes and signaling pathways, in the pathogenesis and progression of endometriosis.

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endometriosis

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References (100)

A comparative study of ovarian and pelvic wall-infiltrating endometriosis via openalex
A Novel Mouse Model of Endometriosis Mimics Human Phenotype and Reveals Insights into the Inflammatory Contribution of Shed Endometrium via openalex
An Overview of Treatments for Endometriosis via openalex
A pilot study on the use of andrographolide to treat symptomatic adenomyosis via openalex
A pilot study to evaluate the clinical relevance of endometriosis-associated nerve fibers in peritoneal endometriotic lesions via openalex
Basic mechanisms of vascularization in endometriosis and their clinical implications via openalex
Cellular Changes Consistent With Epithelial–Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex
Changes in the T-helper cytokine profile and in lymphocyte activation at the systemic and local levels in women with endometriosis via openalex
Co‐culture with macrophages enhances the clonogenic and invasion activity of endometriotic stromal cells via openalex
Complement Pathway Is Frequently Altered in Endometriosis and Endometriosis-Associated Ovarian Cancer via openalex
Constitutive and tumor necrosis factor-α-induced activation of nuclear factor-κB in adenomyosis and its inhibition by andrographolide via openalex
Dating Endometriotic Ovarian Cysts Based on the Content of Cyst Fluid and its Potential Clinical Implications via openalex
Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis via openalex
Endometriosis via openalex
Endometriosis via openalex
Endometriosis, a disease of the macrophage via openalex
Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment via openalex
Endometriosis and infertility: pathophysiology and management via openalex
Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex
Endometriosis: its association with retrograde menstruation, dysmenorrhoea and tubal pathology via openalex
Endometriosis: pathogenesis and treatment via openalex
Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons via openalex
Estrogen and progesterone receptor expression in macrophages and regulation of hepatocyte growth factor by ovarian steroids in women with endometriosis via openalex
Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis via openalex
Eutopic Endometrium in Women with Endometriosis: Ground Zero for the Study of Implantation Defects via openalex
Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility via openalex
Fibrogenesis in Peritoneal Endometriosis via openalex
Fibrogenesis resulting from cyclic bleeding: the Holy Grail of the natural history of ectopic endometrium via openalex
Fibrosis and smooth muscle metaplasia in rectovaginal endometriosis via openalex
Functional and phenotypic alterations in peritoneal macrophages from patients with early and advanced endometriosis via openalex
Histologic Appearance of Endometriosis Infiltrating Uterosacral Ligaments in Women with Painful Symptoms via openalex
Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells via openalex
Hypoxia‐inhibited dual‐specificity phosphatase‐2 expression in endometriotic cells regulates cyclooxygenase‐2 expression via openalex
Imbalance between sympathetic and sensory innervation in peritoneal endometriosis via openalex
Immune-inflammation gene signatures in endometriosis patients via openalex
Immunohistochemical analysis of vascular endothelial growth factor cellular expression in ovarian endometriomata via openalex
Immunosuppressive macrophages induced by IDO1 promote the growth of endometrial stromal cells in endometriosis via openalex
Increased activation of nuclear factor-kappa B (NF-κB) in isolated peritoneal macrophages of patients with endometriosis via openalex
Increased activation of pelvic macrophages in infertile women with mild endometriosis via openalex
Inducers of G-protein coupled estrogen receptor (GPER) in endometriosis: potential implications for macrophages and follicle maturation via openalex
Inhibition of CD36-Dependent Phagocytosis by Prostaglandin E2 Contributes to the Development of Endometriosis via openalex
Interleukin-4 Stimulates Proliferation of Endometriotic Stromal Cells via openalex
Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? via openalex
Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics via openalex
Macrophage Migration Inhibitory Factor Is Involved in Ectopic Endometrial Tissue Growth and Peritoneal-Endometrial Tissue Interaction In Vivo: A Plausible Link to Endometriosis Development via openalex
Macrophages alternatively activated by endometriosis-exosomes contribute to the development of lesions in mice via openalex
Macrophages Are Alternatively Activated in Patients with Endometriosis and Required for Growth and Vascularization of Lesions in a Mouse Model of Disease via openalex
Management of endometriomas in women requiring IVF: to touch or not to touch via openalex
miR-146b level and variants is associated with endometriosis related macrophages phenotype and plays a pivotal role in the endometriotic pain symptom via openalex
Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis via openalex
Pathological functions of hypoxia in endometriosis via openalex
Pathophysiology and Immune Dysfunction in Endometriosis via openalex
Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities via openalex
Peritoneal ﬂuid concentrations of interleukin-4 in relation to the presence of endometriosis, its stage and the phase of the menstrual cycle via openalex
Peritoneal macrophage depletion by liposomal bisphosphonate attenuates endometriosis in the rat model via openalex
Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex
Possible involvement of signal transducer and activator of transcription-3 in cell–cell interactions of peritoneal macrophages and endometrial stromal cells in human endometriosis via openalex
Proangiogenic Tie2+ Macrophages Infiltrate Human and Murine Endometriotic Lesions and Dictate Their Growth in a Mouse Model of the Disease via openalex
P-selectin as a potential therapeutic target for endometriosis via openalex
Rediscovering peritoneal macrophages in a murine endometriosis model via openalex
Role of Estrogens in Inflammatory Response via openalex
Subpopulations of Macrophages within Eutopic Endometrium of Endometriosis Patients via openalex
The importance of the macrophage within the human endometrium via openalex
The second time around: reproductive performance after repetitive versus primary surgery for endometriosis via openalex
Tumor Necrosis Factor-α-Induced Interleukin-8 (IL-8) Expression in Endometriotic Stromal Cells, Probably through Nuclear Factor-κB Activation: Gonadotropin-Releasing Hormone Agonist Treatment Reduced IL-8 Expression via openalex
Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. via openalex
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W171704329 via openalex
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W1967763945 via openalex
W1969015127 via openalex
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W1977631233 via openalex
W1980485314 via openalex
W1982861439 via openalex
W1999935208 via openalex
W2010570319 via openalex
W2019583561 via openalex
W2021740388 via openalex
W2023666964 via openalex
W2026878412 via openalex
W2032639324 via openalex
W2037994205 via openalex
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W2044224359 via openalex
W2045142779 via openalex
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License: CC0 · commercial use OK

[1] A comparative study of ovarian and pelvic wall-infiltrating endometriosis via openalex

[2] A Novel Mouse Model of Endometriosis Mimics Human Phenotype and Reveals Insights into the Inflammatory Contribution of Shed Endometrium via openalex

[3] An Overview of Treatments for Endometriosis via openalex

[4] A pilot study on the use of andrographolide to treat symptomatic adenomyosis via openalex

[5] A pilot study to evaluate the clinical relevance of endometriosis-associated nerve fibers in peritoneal endometriotic lesions via openalex

[6] Basic mechanisms of vascularization in endometriosis and their clinical implications via openalex

[7] Cellular Changes Consistent With Epithelial–Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex

[8] Changes in the T-helper cytokine profile and in lymphocyte activation at the systemic and local levels in women with endometriosis via openalex

[9] Co‐culture with macrophages enhances the clonogenic and invasion activity of endometriotic stromal cells via openalex

[10] Complement Pathway Is Frequently Altered in Endometriosis and Endometriosis-Associated Ovarian Cancer via openalex

[11] Constitutive and tumor necrosis factor-α-induced activation of nuclear factor-κB in adenomyosis and its inhibition by andrographolide via openalex

[12] Dating Endometriotic Ovarian Cysts Based on the Content of Cyst Fluid and its Potential Clinical Implications via openalex

[13] Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis via openalex

[14] Endometriosis via openalex

[15] Endometriosis via openalex

[16] Endometriosis, a disease of the macrophage via openalex

[17] Endometriosis: advances and controversies in classification, pathogenesis, diagnosis, and treatment via openalex

[18] Endometriosis and infertility: pathophysiology and management via openalex

[19] Endometriosis: hormone regulation and clinical consequences of chemotaxis and apoptosis via openalex

[20] Endometriosis: its association with retrograde menstruation, dysmenorrhoea and tubal pathology via openalex

[21] Endometriosis: pathogenesis and treatment via openalex

[22] Endometriosis, retrograde menstruation and peritoneal inflammation in women and in baboons via openalex

[23] Estrogen and progesterone receptor expression in macrophages and regulation of hepatocyte growth factor by ovarian steroids in women with endometriosis via openalex

[24] Estrogen receptor β upregulates CCL2 via NF-κB signaling in endometriotic stromal cells and recruits macrophages to promote the pathogenesis of endometriosis via openalex

[25] Eutopic Endometrium in Women with Endometriosis: Ground Zero for the Study of Implantation Defects via openalex

[26] Expression Profiling of Endometrium from Women with Endometriosis Reveals Candidate Genes for Disease-Based Implantation Failure and Infertility via openalex

[27] Fibrogenesis in Peritoneal Endometriosis via openalex

[28] Fibrogenesis resulting from cyclic bleeding: the Holy Grail of the natural history of ectopic endometrium via openalex

[29] Fibrosis and smooth muscle metaplasia in rectovaginal endometriosis via openalex

[30] Functional and phenotypic alterations in peritoneal macrophages from patients with early and advanced endometriosis via openalex

[31] Histologic Appearance of Endometriosis Infiltrating Uterosacral Ligaments in Women with Painful Symptoms via openalex

[32] Hypoxia-Induced MicroRNA-20a Expression Increases ERK Phosphorylation and Angiogenic Gene Expression in Endometriotic Stromal Cells via openalex

[33] Hypoxia‐inhibited dual‐specificity phosphatase‐2 expression in endometriotic cells regulates cyclooxygenase‐2 expression via openalex

[34] Imbalance between sympathetic and sensory innervation in peritoneal endometriosis via openalex

[35] Immune-inflammation gene signatures in endometriosis patients via openalex

[36] Immunohistochemical analysis of vascular endothelial growth factor cellular expression in ovarian endometriomata via openalex

[37] Immunosuppressive macrophages induced by IDO1 promote the growth of endometrial stromal cells in endometriosis via openalex

[38] Increased activation of nuclear factor-kappa B (NF-κB) in isolated peritoneal macrophages of patients with endometriosis via openalex

[39] Increased activation of pelvic macrophages in infertile women with mild endometriosis via openalex

[40] Inducers of G-protein coupled estrogen receptor (GPER) in endometriosis: potential implications for macrophages and follicle maturation via openalex

[41] Inhibition of CD36-Dependent Phagocytosis by Prostaglandin E2 Contributes to the Development of Endometriosis via openalex

[42] Interleukin-4 Stimulates Proliferation of Endometriotic Stromal Cells via openalex

[43] Is it time for a paradigm shift in drug research and development in endometriosis/adenomyosis? via openalex

[44] Kinase signalling pathways in endometriosis: potential targets for non-hormonal therapeutics via openalex

[45] Macrophage Migration Inhibitory Factor Is Involved in Ectopic Endometrial Tissue Growth and Peritoneal-Endometrial Tissue Interaction In Vivo: A Plausible Link to Endometriosis Development via openalex

[46] Macrophages alternatively activated by endometriosis-exosomes contribute to the development of lesions in mice via openalex

[47] Macrophages Are Alternatively Activated in Patients with Endometriosis and Required for Growth and Vascularization of Lesions in a Mouse Model of Disease via openalex

[48] Management of endometriomas in women requiring IVF: to touch or not to touch via openalex

[49] miR-146b level and variants is associated with endometriosis related macrophages phenotype and plays a pivotal role in the endometriotic pain symptom via openalex

[50] Nuclear factor-kappa B is constitutively activated in peritoneal endometriosis via openalex

[51] Pathological functions of hypoxia in endometriosis via openalex

[52] Pathophysiology and Immune Dysfunction in Endometriosis via openalex

[53] Peritoneal endometriosis, ovarian endometriosis, and adenomyotic nodules of the rectovaginal septum are three different entities via openalex

[54] Peritoneal ﬂuid concentrations of interleukin-4 in relation to the presence of endometriosis, its stage and the phase of the menstrual cycle via openalex

[55] Peritoneal macrophage depletion by liposomal bisphosphonate attenuates endometriosis in the rat model via openalex

[56] Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex

[57] Possible involvement of signal transducer and activator of transcription-3 in cell–cell interactions of peritoneal macrophages and endometrial stromal cells in human endometriosis via openalex

[58] Proangiogenic Tie2+ Macrophages Infiltrate Human and Murine Endometriotic Lesions and Dictate Their Growth in a Mouse Model of the Disease via openalex

[59] P-selectin as a potential therapeutic target for endometriosis via openalex

[60] Rediscovering peritoneal macrophages in a murine endometriosis model via openalex

[61] Role of Estrogens in Inflammatory Response via openalex

[62] Subpopulations of Macrophages within Eutopic Endometrium of Endometriosis Patients via openalex

[63] The importance of the macrophage within the human endometrium via openalex

[64] The second time around: reproductive performance after repetitive versus primary surgery for endometriosis via openalex

[65] Tumor Necrosis Factor-α-Induced Interleukin-8 (IL-8) Expression in Endometriotic Stromal Cells, Probably through Nuclear Factor-κB Activation: Gonadotropin-Releasing Hormone Agonist Treatment Reduced IL-8 Expression via openalex

[66] Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids. via openalex

[67] W6606991537 via openalex

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[69] W6636340423 via openalex

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