The second time around: reproductive performance after repetitive versus primary surgery for endometriosis
article
OA: closed
CC0
⤵ 47 in-corpus citations
AI-generated summary
This study evaluated the reproductive outcomes of women undergoing repeat surgeries for endometriosis compared to those having primary surgery.
One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works
Abstract
After repetitive surgery for recurrent endometriosis, 20 of 89 (22%) women achieved spontaneous pregnancy, compared with 165 of 411 (40%) after first-line procedure (adjusted incidence rate ratio, 0.51; 95% confidence interval, 0.32 to 0.82), and the 12- and 24-month cumulative pregnancy rates were 14% and 26% in the former group compared with 32% and 38% in the latter. Among infertile patients at baseline, 13 of 67 (19%) conceived after reoperation compared with 98 of 290 (34%) after primary surgery (adjusted incidence rate ratio, 0.55; 95% confidence interval, 0.30 to 0.99), and the 12- and 24-month cumulative pregnancy rates were 13% and 22% in the former group and 25% and 30% in the latter.
My notes (saved in your browser only)
Condition tags
MeSH descriptors
Citation neighborhood
Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.
References (23)
- Effect of endometriosis on in vitro fertilization via openalex
- Endometriosis and infertility via openalex
- Endometriosis: recurrence and retreatment. via openalex
- Infertility surgery is dead: only the obituary remains? via openalex
- Laparoscopy, in vitro fertilization, and endometriosis: an enigma via openalex
- Laparotomy in infertility patients with endometriosis. Use of the CO2 laser. via openalex
- Repetitive conservative surgery for recurrence of endometriosis. via openalex
- Reproductive performance, pain recurrence and disease relapse after conservative surgical treatment for endometriosis: the predictive value of the current classification system via openalex
- Should endometriomas be treated before IVF–ICSI cycles? via openalex
- Surgery for endometriosis-associated infertility: a pragmatic approach via openalex
- The outcome of in vitro fertilization in advanced endometriosis with previous surgery: A case-controlled study via openalex
- W2048981943 via openalex
- W2041530351 via openalex
- W2041164052 via openalex
- W2160615352 via openalex
- W2030208756 via openalex
- W1977520875 via openalex
- W2477008945 via openalex
- W6607528678 via openalex
- W6658477549 via openalex
- W6715784199 via openalex
- W2079190330 via openalex
- W6718155611 via openalex
Cited by (47)
- Predictive factors for spontaneous conception in women with moderate and severe endometriosis following operative laparoscopy: A cohort study 2025
- Pathophysiology and Clinical Implications of Ovarian Endometriomas 2024
- Presence of endometrioma decreased blastocyst formation rate but not impair Assisted Reproductive Technology (ART) outcome 2023
- Morphokinetic analysis of early human embryonic development and its relationship to endometriosis resection: a retrospective time-lapse study using the KIDScore™ D3 and D5 implantation data algorithm 2023
- What is the impact of endometrioma on IVF/ICSI outcomes in patients with endometriosis: A retrospective study 2022
- Presence of Endometrioma Decreased Blastocyst Formation Rate but Not Impair Assisted Reproductive Technology (ART) outcome 2022
- Effect of the mode of delivery on the risk of endometriosis recurrence: a retrospective cohort study 2022
- Preoperative and perioperative intervention reduces the risk of recurrence of endometriosis in mice caused by either incomplete excision or spillage and dissemination 2021
- COUNCELING PATIENTS WITH ENDOMETRIOSIS 2021
- The roles and functions of macrophages in endometriosis 2021
- Long-term Recurrence of Endometriosis in Women with Subfertility Caused by Endometriosis: A Comparison of the Efficacy of Surgery and Assisted Reproductive Technology as Fertilization Treatment Approaches 2020
- The perioperative period: a critical yet neglected time window for reducing the recurrence risk of endometriosis? 2019
- Fertility Preservation in Women with Endometriosis: It is About Time We Talk About it! 2019
- Perioperative Intervention by β-Blockade and NF-κB Suppression Reduces the Recurrence Risk of Endometriosis in Mice Due to Incomplete Excision 2019
- Use of the Endometriosis Fertility Index to Predict Natural Pregnancy after Endometriosis Surgery: A Single-Center Study 2018
- Recurrent endometriosis and IVF: is it still an enigma? 2018
- To operate or not to operate on women with deep infiltrating endometriosis (DIE) before in vitro fertilization (IVF) 2017
- Which is worse? Comparison of ART outcome between women with primary or recurrent endometriomas 2017
- Management of Endometriosis: Toward Value-Based, Cost-Effective, Affordable Care 2017
- Which is worse? A comparison of ART outcome between women with primary or recurrent endometriomas 2017
- Estrogen-progestins and progestins for the management of endometriosis 2016
- The Efficacy of Postoperative Cyclic Oral Contraceptives after Gonadotropin-Releasing Hormone Agonist Therapy to Prevent Endometrioma Recurrence in Adolescents 2016
- Deep infiltrating endometriosis affecting the urinary tract—surgical treatment and fertility outcomes in 2004–2013 2016
- Endometriosis-related infertility: ovarian endometrioma<i>per se</i>is not associated with presentation for infertility 2016
- Fertility preservation in women with endometriosis: for all, for some, for none? 2015
- Exploring the Relationship between Endometriomas and Infertility 2015
- Effect of second-line surgery on<i>in vitro</i>fertilization outcome in infertile women with ovarian endometrioma recurrence after primary conservative surgery for moderate to severe endometriosis 2015
- Surgery for endometriosis-associated infertility: do we exaggerate the magnitude of effect? 2015
- An Update on Surgical versus Expectant Management of Ovarian Endometriomas in Infertile Women 2015
- External Validation of the Endometriosis Fertility Index (EFI) for Predicting Spontaneous Pregnancy after Surgery: Further Considerations on Its Validity 2015
- Second surgery for recurrent endometriomas is more harmful to healthy ovarian tissue and ovarian reserve than first surgery 2015
- Endometriosis and Infertility: How and When to Treat? 2014
- Ovarijska rezerva prije i nakon operacije endometrioma 2014
- Recurrence of ovarian endometrioma after second-line, conservative, laparoscopic cyst enucleation 2013
- Role of Surgery in Endometriosis-Associated Subfertility 2013
- Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference? 2013
- Comparisons Between Laparoscopy Only Versus In Vitro Fertilization in Combination With Laparoscopy for Increasing Probability of Pregnancy in Patients with Endometriosis Associated Infertility 2012
- Endometriosis and Infertility – a consensus statement from <scp>ACCEPT</scp> (Australasian <scp>CREI</scp> Consensus Expert Panel on Trial evidence) 2012
- Ovarian endometrioma: guidelines for selection of cases for surgical treatment or expectant management 2012
- Long‐term adjuvant therapy for the prevention of postoperative endometrioma recurrence: a systematic review and meta‐analysis 2012
- Surgical Therapies: Peritoneal Endometriosis Surgery 2011
- Endometriosis of the Round Ligament of the Uterus 2011
- Post-operative endometriosis recurrence: a plea for prevention based on pathogenetic, epidemiological and clinical evidence 2010
- Endometriosis-associated infertility: surgery and IVF, a comprehensive therapeutic approach 2010
- Repeat transvaginal ultrasound-guided aspiration of ovarian endometrioma in infertile women with endometriosis 2010
- The outcomes of repeat surgery for recurrent symptomatic endometriosis 2010
- The effect of second‐line surgery on reproductive performance of women with recurrent endometriosis: A systematic review 2009
Source provenance
- europepmc
- last seen: 2026-08-06T06:07:45.168820+00:00
- openalex
- last seen: 2026-06-10T17:14:06.276822+00:00
- pubmed
- last seen: 2026-05-13T22:14:05.573375+00:00
License: CC0
· commercial use OK