Oral contraceptives in the prevention of endometrioma recurrence: does the different progestins used make a difference?

Gaspare Cucinella, Roberta Granese, Glória Calagna, Gloria Calagna, Alessandro Svelato, Salvatore Saitta, Gabriele Tonni, Pasquale De Franciscis, Nicola Colacurci, A Perino, Antonino Perino
Archives of gynecology and obstetrics · 2013 · vol. 288(4) , pp. 821–827 · doi:10.1007/s00404-013-2841-9 · PMID:23580011 · W2023903557
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study found that long-term oral contraceptive use after laparoscopic endometrioma excision significantly reduced recurrence compared to no hormonal therapy, with no difference noted between progestin types.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This multicenter study evaluated endometrioma recurrence after conservative laparoscopic excision followed by long-term oral contraceptive therapy, comparing three progestins (desogestrel, gestodene, dienogest) in a randomized design and including an observational control group of women who refused postoperative hormonal therapy. Among 168 women, 21/131 (12.5%) had endometrioma recurrence over 24 months, and recurrence was significantly higher in non-users than in women receiving long-term OCs. Differences between the three progestin groups were not statistically significant, and the authors excluded women with ultrasound persistence of endometrioma at 1 month from the analysis, which may limit generalizability to early non-response. This paper is centrally about endometriosis — it examines how different oral contraceptive progestins affect ovarian endometrioma recurrence prevention after laparoscopic excision.

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Condition tags

mesh:D004715endometrioma

MeSH descriptors

Contraceptives, Oral Desogestrel Endometriosis Nandrolone Norpregnenes Ovarian Diseases Adolescent Adult Combined Modality Therapy Contraceptives, Oral Desogestrel Drug Administration Schedule Endometriosis Endometriosis Female Follow-Up Studies Humans Kaplan-Meier Estimate Laparoscopy Nandrolone

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (35)

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