Postoperative oral contraceptive exposure and risk of endometrioma recurrence

Paolo Vercellini, Edgardo Somigliana, Daguati R, Raffaella Daguati, Paola Vigano, Paola Viganò, Francesca Meroni, Meroni F, Pier Giorgio Crosignani, Crosignani PG
American journal of obstetrics and gynecology · 2008 · vol. 198(5) , pp. 504.e1–504.e5 · doi:10.1016/j.ajog.2007.11.010 · PMID:18241819 · W1982594575
article OA: closed CC0 ⤵ 165 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-06 ⓘ

This study investigated whether exposure to oral contraceptives after surgery for endometrioma impacts the recurrence rate of the condition.

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Abstract

ObjectiveThe purpose of this study was to compare the postoperative risk of endometrioma recurrence in women using oral contraception and in those undergoing simple observation.Study designAfter laparoscopic excision of ovarian endometriotiomas, a cyclic, low-dose, monophasic oral contraceptive pill (OCP) was offered to women not seeking pregnancy. One month after surgery, and every 6 months afterward, the patients underwent clinical and ultrasonographic assessment.ResultsOf the 277 patients who entered the study, 102 used OCP for the entire follow-up period (always users), 129 used OCP discontinuously (ever users), and 46 declined treatment (never users). The median follow-up was 28 months. Recurrent endometriotic cysts were detected in 74 subjects (27%). The 36-month cumulative proportion of subjects free from endometrioma recurrence was 94% in the always users compared with 51% in the never users (P < .001); adjusted incidence rate ratio (IRR) = 0.10 (95% CI, 0.04-0.24).ConclusionRegular postoperative use of OCP effectively prevents endometrioma recurrence.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Contraceptives, Oral Endometriosis Endometriosis Ovarian Diseases Ovarian Diseases Adult Contraceptives, Oral Endometriosis Endometriosis Female Humans Laparoscopy Logistic Models Ovarian Diseases Ovarian Diseases Postoperative Period Proportional Hazards Models Recurrence Ultrasonography

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References (27)

Cited by (50)

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