Postoperative oral contraceptive exposure and risk of endometrioma recurrence

Paolo Vercellini, Edgardo Somigliana, Daguati R, Raffaella Daguati, Paola Vigano, Paola Viganò, Francesca Meroni, Meroni F, Pier Giorgio Crosignani, Crosignani PG
American journal of obstetrics and gynecology · 2008 · vol. 198(5) , pp. 504.e1–504.e5 · doi:10.1016/j.ajog.2007.11.010 · PMID:18241819 · W1982594575
Other OA: closed CC0 ⤵ 165 in-corpus citations
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This study investigated whether exposure to oral contraceptives after surgery for endometrioma impacts the recurrence rate of the condition.

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Abstract

OBJECTIVE: The purpose of this study was to compare the postoperative risk of endometrioma recurrence in women using oral contraception and in those undergoing simple observation. STUDY DESIGN: After laparoscopic excision of ovarian endometriotiomas, a cyclic, low-dose, monophasic oral contraceptive pill (OCP) was offered to women not seeking pregnancy. One month after surgery, and every 6 months afterward, the patients underwent clinical and ultrasonographic assessment. RESULTS: Of the 277 patients who entered the study, 102 used OCP for the entire follow-up period (always users), 129 used OCP discontinuously (ever users), and 46 declined treatment (never users). The median follow-up was 28 months. Recurrent endometriotic cysts were detected in 74 subjects (27%). The 36-month cumulative proportion of subjects free from endometrioma recurrence was 94% in the always users compared with 51% in the never users (P < .001); adjusted incidence rate ratio (IRR) = 0.10 (95% CI, 0.04-0.24). CONCLUSION: Regular postoperative use of OCP effectively prevents endometrioma recurrence.

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Condition tags

endometriosisendometrioma

MeSH descriptors

Contraceptives, Oral Endometriosis Endometriosis Ovarian Diseases Ovarian Diseases Adult Adult Contraceptives, Oral Contraceptives, Oral Endometriosis Endometriosis Endometriosis Female Female Humans Humans Laparoscopy Laparoscopy Logistic Models Logistic Models

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (27)

Cited by (50)

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