The presence of ovarian endometriomas is associated with a reduced responsiveness to gonadotropins

Edgardo Somigliana, Infantino M, M. Silva Infantino, Mirco Infantino, Francesca Benedetti, Benedetti F, Arnoldi M, Mariangela Arnoldi, Graziella Calanna, Calanna G, Guido Ragni, G. Ragni, Ragni G
Fertility and sterility · 2006 · vol. 86(1) , pp. 192–196 · doi:10.1016/j.fertnstert.2005.12.034 · PMID:16716316 · W1993646024
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Ovarian endometriomas are associated with decreased ovarian responsiveness to gonadotropin stimulation, impacting fertility treatments.

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Abstract

ObjectiveTo clarify whether the presence of ovarian endometriomas is associated with a reduced responsiveness to ovarian hyperstimulation.DesignObservational study.SettingUniversity teaching hospital.Patient(s)Women selected for in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) cycles who were found to have unilateral ovarian endometriomas and who did not undergo previous ovarian surgery.Intervention(s)Ovarian hyperstimulation using gonadotropins.Main outcome measure(s)Number of codominant follicles (mean diameter >15 mm) in the affected and in the contralateral intact gonads.Result(s)Thirty-six patients were enrolled. They underwent 56 IVF-ICSI cycles. The number of codominant follicles in the intact and affected ovaries were 4.0 +/- 2.2 and 3.0 +/- 1.7, respectively (P=.01). This difference corresponded to a mean reduction (95% confidence interval [CI]) of 25% (6%-44%). This deleterious effect was more evident in women with larger cysts, in those with more than one cyst, and in those who were more responsive to ovarian hyperstimulation.Conclusion(s)The presence of ovarian endometriomas is associated with a reduced responsiveness to gonadotropins.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropins Infertility, Female Infertility, Female Ovarian Diseases Ovarian Follicle Ovulation Induction Adult Comorbidity Endometriosis Endometriosis Female Gonadotropins Humans Incidence Infertility, Female Infertility, Female Italy Italy Ovarian Diseases

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