The presence of ovarian endometriomas is associated with a reduced responsiveness to gonadotropins

Edgardo Somigliana, Infantino M, M. Silva Infantino, Mirco Infantino, Francesca Benedetti, Benedetti F, Arnoldi M, Mariangela Arnoldi, Graziella Calanna, Calanna G, Guido Ragni, G. Ragni, Ragni G
Fertility and sterility · 2006 · vol. 86(1) , pp. 192–196 · doi:10.1016/j.fertnstert.2005.12.034 · PMID:16716316 · W1993646024
Non-randomised trial OA: closed CC0 ⤵ 130 in-corpus citations
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Ovarian endometriomas are associated with decreased ovarian responsiveness to gonadotropin stimulation, impacting fertility treatments.

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Abstract

OBJECTIVE: To clarify whether the presence of ovarian endometriomas is associated with a reduced responsiveness to ovarian hyperstimulation. DESIGN: Observational study. SETTING: University teaching hospital. PATIENT(S): Women selected for in vitro fertilization-intracytoplasmic sperm injection (IVF-ICSI) cycles who were found to have unilateral ovarian endometriomas and who did not undergo previous ovarian surgery. INTERVENTION(S): Ovarian hyperstimulation using gonadotropins. MAIN OUTCOME MEASURE(S): Number of codominant follicles (mean diameter >15 mm) in the affected and in the contralateral intact gonads. RESULT(S): Thirty-six patients were enrolled. They underwent 56 IVF-ICSI cycles. The number of codominant follicles in the intact and affected ovaries were 4.0 +/- 2.2 and 3.0 +/- 1.7, respectively (P=.01). This difference corresponded to a mean reduction (95% confidence interval [CI]) of 25% (6%-44%). This deleterious effect was more evident in women with larger cysts, in those with more than one cyst, and in those who were more responsive to ovarian hyperstimulation. CONCLUSION(S): The presence of ovarian endometriomas is associated with a reduced responsiveness to gonadotropins.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Gonadotropins Infertility, Female Infertility, Female Ovarian Diseases Ovarian Follicle Ovulation Induction Adult Adult Comorbidity Comorbidity Endometriosis Endometriosis Endometriosis Female Female Gonadotropins Gonadotropins Humans Humans

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References (32)

Cited by (50)

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