Effects of Endometriomas on Ooccyte Quality, Embryo Quality, and Pregnancy Rates in In Vitro Fertilization Cycles: A Prospective, Case-Controlled Study

E H Yanushpolsky, Elena Yanushpolsky, C L Best, Craig L. Best, Katharine V. Jackson, K V Jackson, Robert N. Clarke, R N Clarke, R L Barbieri, Robert L. Barbieri, Mark D. Hornstein, M D Hornstein
Journal of assisted reproduction and genetics · 1998 · vol. 15(4) , pp. 193–197 · doi:10.1023/a:1023048318719 · PMID:9565848 · W1502831380
article OA: bronze CC0 ⤵ 118 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

Endometriomas were associated with higher early pregnancy loss rates, and potentially fewer oocytes retrieved and poorer embryo quality compared to women without complex cysts.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This prospective case-control study evaluated whether endometriomas present at the time of oocyte retrieval affect IVF outcomes by comparing 45 women with “chocolate” cysts (with cyst fluid CA 125 measured to distinguish true endometriomas) versus 57 controls without complex ovarian cysts. IVF outcomes were assessed in relation to oocyte quantity/quality proxies, embryo development (including reaching at least the four-cell stage 48 hours after retrieval), and pregnancy outcomes. Women with true endometriomas had a significantly higher rate of early pregnancy loss (47% vs 14%) and showed a trend toward fewer oocytes retrieved and fewer embryos reaching the four-cell stage. Limitations include the modest sample size and the observational design, which restricts firm causal inference about mechanisms. This paper is centrally about endometriosis—specifically, how endometriomas at IVF oocyte retrieval relate to oocyte quality, embryo quality, and early pregnancy loss rates.

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Condition tags

mesh:D004715

MeSH descriptors

Embryo, Mammalian Endometriosis Fertilization in Vitro Oocytes Pregnancy Rate CA-125 Antigen CA-125 Antigen Case-Control Studies Demography Embryo, Mammalian Endometriosis Endometriosis Female Humans Oocytes Ovarian Cysts Ovarian Cysts Ovarian Cysts Pregnancy Pregnancy Complications

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