Comparison of Cycle Outcomes Among Women with Endometrioma or Non-Functional Cysts Versus Control

Enis Özkaya, Ebru Çöğendez, Elif Tozkır, Saadet Unsal, Ahmet Yavuz, Gülden Tunalı, Özgür Uzun, Evrim Bostancı Ergen, S Eser
In: Gynecology Obstetrics & Reproductive Medicine · 2021 · pp. 1–6 · doi:10.21613/gorm.2020.1110 · W3121360433
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⚙ AI-generated summary by claude@2026-07, 2026-07-09 ⓘ

Women with non-functional ovarian cysts, compared to those with endometrioma or no cysts, experienced lower clinical pregnancy rates in IVF cycles, suggesting cystic masses are a risk factor for poor outcomes.

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⚙ AI-generated deep summary by claude@2026-07, 2026-07-09 · read from full text ⓘ

This study compared IVF cycle outcomes in women under 35 with endometrioma (n=82) or non-functional ovarian cysts (n=100) versus a control group (n=117) with unexplained infertility, using consecutively selected participants matched for age and ovarian reserve. Groups were similar in baseline age, early follicular FSH, AMH, and antral follicle counts, but differed in starting and total gonadotropin dose, peak estradiol, total oocyte number, and mature oocyte numbers. Clinical pregnancy rates were lower in non-functional cysts (10.7%) and endometrioma (17.3%) than in controls (31.6%), and the presence of a non-functional cystic mass at stimulation start was reported as a risk factor for poor clinical pregnancy outcome (OR=0.5, 95% CI 0.2–0.9). This paper is centrally about endometriosis — it directly evaluates IVF cycle outcomes for women with endometrioma compared with controls and women with non-functional cysts.

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Abstract

OBJECTIVE: This study aimed to compare cycle outcomes among women with endometrioma or non-functional cysts versus control. STUDY DESIGN: Women under 35 years of age with unexplained infertility underwent in vitro fertilization cycle. Two hundred and ninety-nine women were included in this study. Study groups consist of women with endometrioma (n=82) or non-functional ovarian cysts (n=100) and control group (n=117). Women in each group were selected consecutively. Groups were matched for age and ovarian reserve and compared in terms of in vitro fertilization cycle outcome. RESULTS: There were no significant differences among groups in terms of mean age, early follicular phase Follicle-Stimulating Hormone, and anti-müllerian hormone levels (p>0.05). Baseline total antral follicle counts were similar among groups (p>0.05). There were significant differences among groups in terms of mean starting and total gonadotropin dose, peak estradiol level, total oocyte number, and mature oocyte numbers (p<0.05). Clinical pregnancy rates were 10.7%, 17.3%, and 31.6% in groups with non-functional cyst, endometrioma and control group respectively (p<0.05). The presence of a non-functional cystic mass of ovary on the starting day of stimulation was a risk factor for poor cycle outcome in terms of clinical pregnancy rates [OR=0.5 (95 % CI; 0.2-0.9, p=0.03)]. CONCLUSION: Our data showed that the presence of any kind of cystic mass of the ovary especially the non-functional cysts on the starting day of stimulation was a risk factor for poor cycle outcomes in terms of clinical pregnancy rates.
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Objective

This study aimed to compare cycle outcomes among women with endometrioma or non-functional cysts versus control. STUDY DESIGN: Women under 35 years of age with unexplained infertility underwent in vitro fertilization cycle. Two hundred and ninety-nine women were included in this study. Study groups consist of women with endometrioma (n=82) or non-functional ovarian cysts (n=100) and control group (n=117). Women in each group were selected consecutively. Groups were matched for age and ovarian reserve and compared in terms of in vitro fertilization cycle outcome.

Results

There were no significant differences among groups in terms of mean age, early follicular phase Follicle-Stimulating Hormone, and anti-müllerian hormone levels (p>0.05). Baseline total antral follicle counts were similar among groups (p>0.05). There were significant differences among groups in terms of mean starting and total gonadotropin dose, peak estradiol level, total oocyte number, and mature oocyte numbers (p<0.05). Clinical pregnancy rates were 10.7%, 17.3%, and 31.6% in groups with non-functional cyst, endometrioma and control group respectively (p<0.05). The presence of a non-functional cystic mass of ovary on the starting day of stimulation was a risk factor for poor cycle outcome in terms of clinical pregnancy rates [OR=0.5 (95 % CI; 0.2-0.9, p=0.03)].

Conclusion

Our data showed that the presence of any kind of cystic mass of the ovary especially the non-functional cysts on the starting day of stimulation was a risk factor for poor cycle outcomes in terms of clinical pregnancy rates. Downloads Downloads Published How to Cite Issue Section License Copyright (c) 2021 Enis Ozkaya, Ebru Cogendez, Elif Tozkir, Saadet Unsal, Ahmet Yavuz, Gulden Tunali, Ozgur Uzun, Evrim Bostancı Ergen, Semra Kayatas Eser This work is licensed under a Creative Commons Attribution 4.0 International License. All the articles published in GORM are licensed with "Creative Commons Attribution 4.0 License (CC BY 4.0)". This license entitles all parties to copy, share and redistribute all the articles, data sets, figures and supplementary files published in this journal in data mining, search engines, web sites, blogs and other digital platforms under the condition of providing references.

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endometriomainfertility

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