Impact of The Endometrioma on Ovarian Response and Pregnancy Rate in In Vitro Fertilization Cycles
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Ovarian endometrioma negatively impacted ovarian response by reducing oocyte retrieval and metaphase II oocytes, but did not affect embryo quality or pregnancy rates in IVF cycles.
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Abstract
Background: Our objective was to evaluate the effect of ovarian endometrioma on ovarian
\nstimulation outcomes in in vitro fertilization cycles (IVF).
\nMaterials and Methods: In this prospective cohort study, we followed 103 patients who
\nunderwent intra-cytoplasmic sperm injection (ICSI) procedures over a 24-months period.
\nThe study group consisted of 47 infertile women with either unilateral or bilateral ovarian
\nendometrial cysts of less than 3 cm. The control group consisting of 57 patients with mild
\nmale factor infertility was candidate for ICSI treatment during the same time period as
\nthe study groups. Both groups were compared for number of oocytes retrieved, grades of
\noocytes, as well as embryo quantity and quality.
\nResults: Our results showed similar follicle numbers, good embryo grades (A or B)
\nand pregnancy rates in the compared groups. However, patients with endometrioma had
\nhigher gonadotropin consumption than the control group. The mean number of retrieved
\noocytes in patients with endometrioma was significantly lower than control group (6.6
\n± 3.74 vs. 10.4 ± 5.25) (p<0.001). In addition, patients with endometrioma had significantly
\nlower numbers of metaphase II (MII) oocytes (5 ± 3.21) than controls (8.2 ± 5.4)
\n(p<0.001). In patients with unilateral endometrioma, there were no significant differences
\nin main outcome measures between normal and involved ovaries in the patients with
\nendometrioma.
\nConclusion: Patients with ovarian endometrioma had poor outcome. They showed poor ovarian
\nresponse with lower total numbers of retrieved oocytes and lower MII oocytes during the
\nstimulation phase; however, it does not affect the total number of embryos transferred per patient,
\nquality of embryos, and pregnancy rate per patient.
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Cited by (21)
- Endometriosis and IVF: Clinical, Surgical, and Biological Factors Affecting Outcomes 2025
- The Effect of Endometriosis on In Vitro Fertilization Outcomes: A Systematic Review and Meta-Analysis 2024
- Ovarian Stimulation for In Vitro Fertilization and Reproductive Outcome after Surgical Treatment of Endometriosis Compared with Tubal Factor Infertility 2023
- Endometriosis, Oocyte and Embryo Quality 2023
- Endometriosis, Oocyte, and Embryo Quality 2023
- Reproductive outcomes of IVF after comprehensive endometriosis treatment: a prospective cohort study 2022
- Influence of endometrioma size on ART outcomes 2022
- The Impact of Endometriosis on Embryo Quality in in-vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis 2021
- Comparison of Cycle Outcomes Among Women with Endometrioma or Non-Functional Cysts Versus Control 2021
- The impact of endometrioma size on ovarian responsiveness 2020
- Impacts of medroxyprogesterone acetate on oocytes and embryos: matched case-control study in women with stage III–IV ovarian endometriosis undergoing controlled ovarian hyperstimulation for in vitro fertilization 2020
- Impact of endometrioma and bilaterality on IVF / ICSI cycles in patients with endometriosis 2020
- Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis 2019
- Endometrioma, fertility, and assisted reproductive treatments: connecting the dots 2018
- Endométriome et prise en charge en FIV, RPC Endométriose CNGOF-HAS 2018
- Traitement conservateur des endométriomes chez les patientes prises en charge en FIV 2017
- Treatment of endometrioma for improving fertility 2016
- The Impact of Ovarian Endometrioma(s) on ART Outcomes: Retrospective Case Control Study 2016
- Ovarian response is a better predictor of clinical pregnancy rate following embryo transfer than is thin endometrium or presence of an endometrioma 2015
- The impact of endometrioma on IVF/ICSI outcomes: a systematic review and meta-analysis 2015
- Impact of ovarian endometrioma on ovarian responsiveness and IVF: a systematic review and meta-analysis 2015
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