Long Agonist or Short Antagonist Protocol in Women with Intact Endometrioma(s) Undergoing ICSI: Retrospective Analysis

O Ob bj je ec ct ti iv ve e: : Is to evaluate the efficacy of different ovarian stimulation (OS) protocols in patients with intact endometrioma(s) undergoing ICSI. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Retrospective chart review was performed. A total of 717 women were detected to have endometriosis of which 165 women with intact endometrioma(s) were included in the final analysis. A total of 60 women were detected in long agonist (AG) and 105 in short antagonist protocol (ANT). Sub-group analysis was performed to document OS outcomes of poor responders fulfilling the Bologna criteria. R Re es su ul lt ts s: : Significantly shorter cycle duration and lower gonadotropin consumption was observed with ANT protocol compared to AG (p<0.001). The OS outcomes in terms of implantation, ongoing pregnancy (OP) and live birth rate per started cycle (LBR) were comparable in both groups. Overall LBR was 22,4%. Both protocols revealed similar but poor reproductive outcomes in terms of ongoing pregnancy (11.1%) and live birth rates (7.4%) in poor responders. C Co on nc cl lu us si io on n: : AG or ANT protocols seemed to be equally effective in terms of oocyte yield and LBRs in women with intact endometrioma undergoing OS. Shorter duration and lower gonadotropin consumption may be attributed to the convenience of ANT protocol. In poor responders, reproductive outcomes are still not satisfactory with either protocol K Ke ey yw wo or rd ds s: : Agonist protocol; antagonist protocol; endometriomas Z ZE ET T A Am ma a : : ICSI uygulanan intakt endometrioma hastalarnda farkl ovaryan stimlasyon protokollerinin etkinliini deerlendirmektir. G Ge er re e v ve e Y Y n nt te em ml le er r: : alma Retrospektif olarak yapld. Endometriosisi olan toplam 717 kadn almaya dahil edildi. Bunlardan intak endometriomas olan 165 kadn nihayi analize dahil edildi. Uzun agonist protokol 60 kadna ve short antagonist protokolde toplam 105 kadna uyguland. Alt grup analizi, Bologna kriterlerini yerine getiren poor responderlerin ovulasyon stimulasyon sonularn dkmente etmek iin gerekletirildi. B Bu ul lg gu ul la ar r: : Antagonist protokolde agoniste gre anlaml derecede daha ksa siklus sresi ve dk gonadotropin tketimi gzlendi (p<0,001). Her iki grupta da, implantasyon, devam eden gebelik ve siklus bana canl doum oran asndan ovulasyon stimulasyon sonular benzerdi. Canl doum oran %22,4 idi. Her iki protokolde benzer sonular ortaya ikard.Ama poor responderlarda devam eden gebelik (%11,1), canl doum oranlar (%7,4) asndan zayf reme sonular ortaya kmtr. S So on nu u : : Agonist veya antagonist protokolleri, intak endometrioma olan kadnlarda oosit eldesi ve canl doum oran asndan