Detrimental effects of endometriosis on oocyte morphology in intracytoplasmic sperm injection cycles: a retrospective cohort study

Kasapoglu I, Işıl Kasapoğlu, Isil Kasapoglu, Kuspinar G, Göktan Kuspinar, Göktan Kuşpınar, Seda Saribal, Saribal S, Pinar Turk, Pınar Türk, Avcı B, Berrin Avcı, Gürkan Uncu, Uncu G
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2017 · vol. 34(3) , pp. 206–211 · doi:10.1080/09513590.2017.1391203 · PMID:29057690 · W2766514076
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This study found that oocytes from women with endometriosis exhibited significantly higher rates of morphological abnormalities, including dark cytoplasm and abnormal polar bodies, compared to women with male factor infertility.

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Abstract

While an association can be addressed among endometriosis and subfertility, the causal relationship has not been elucidated yet. Impaired oocyte quality in endometriosis patients has been accused for the unsuccessful outcomes of assisted reproductive techniques. There are limited studies in literature evaluated association between endometriosis and oocyte morphology. We conducted this retrospective study to evaluate whether morphological abnormalities of oocytes are more common in women with endometriosis than women with diagnosis of male factor infertility as a source of healthy oocytes. Totally 1568 oocytes, 775 (49.4%) in endometriosis groups and 793 (50.6%) in control group were evaluated for morphological parameters before ICSI cycles. Abnormal oocyte morphology was detected in 352 (22.4%) of 1568 oocytes. Of the abnormal oocytes, 208 (59.1%) were in endometriosis group and 144 (40.9%) in control group (p < .001). The following dysmorphisms were significantly higher in oocytes retrieved from endometriosis group: dark cytoplasm; dark, large or thin zona pellucida; and flat or fragmented polar body (p < .05 for all). When morphological parameters for oocytes of endometriosis patients evaluated, the oocyte defects has increased significantly in endometriosis patients. These findings are thought to be useful to clarify the subfertility in endometriosis patient, which needs to be confirmed with further studies.

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Condition tags

endometriosisinfertility

MeSH descriptors

Endometriosis Infertility, Female Oocytes Adult Cell Shape Cell Shape Embryo Transfer Endometriosis Female Humans Infertility, Female Oocyte Retrieval Oocytes Pregnancy Pregnancy Rate Retrospective Studies Sperm Injections, Intracytoplasmic

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Cited by (29)

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