Characteristics of adenomyosis in secondary infertility patients on MRI and factors associated with fertility recovery after HIFU

Zhiyun Yang, Jinfeng Lin, Tao Tan, Yuan Li, Ying Chen, Meijie Yang, Zhibo Xiao, Jinyun Chen
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2025 · vol. 42(1) , pp. 2550633 · doi:10.1080/02656736.2025.2550633 · PMID:41414952 · W4413719241
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study identified MRI features of adenomyosis, such as T2WI high-signal spots and type II lesions, associated with secondary infertility and found that younger age improved pregnancy outcomes after HIFU treatment.

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Abstract

OBJECTIVE: To study the MRI characteristics of adenomyosis in secondary infertility patients, and to analyze the factors affecting pregnancy after High-intensity focused ultrasound (HIFU). METHODS: Clinical data of 388 patients with adenomyosis were selected from January 2014 to December 2019 treated with HIFU They were divided into the infertility group and the control group by the presence of secondary infertility. Then the patients in the infertile group who had fertility requirements after HIFU were divided into the postoperative pregnancy group and the non-pregnant group, to assess the MRI characteristics of adenomyosis and the factors affecting infertility and to analyze the factors affecting fertility recovery after HIFU. RESULTS: Seventeen (28.81%) of the patients in the infertile group obtained pregnancy after HIFU. Type II (exogenous) lesions, T2-weighted image(T2WI) high-signal spots more than 30, pelvic adhesions, and dysmenorrhea may be related factors affecting the conception of patients with adenomyosis, among which T2WI high-signal spots more than 30 (OR = 1.810, 95CI%: 1.071-3.058) was an independent risk factor for infertility (p < 0.05). There was no significant effect on whether fertilization in patients with pelvic adhesions, while age (OR = 0.844, 95CI%: 0.719-0.990) was an independent influence on whether pregnancy occurred after HIFU (p < 0.05), and the postoperative conception rate was high when the age was less than 37 years. CONCLUSION: T2WI high-signal spots in lesions more than 30, type II (exogenous) lesions, pelvic adhesions, and dysmenorrhea symptoms are risk factors for secondary infertility in patients with adenomyosis. HIFU treatment has the potential to enhance fertility in some patients with uterine adenomyosis. Age serves as an independent factor significantly influencing pregnancy outcomes following HIFU surgery. Consequently, early intervention is recommended for patients with uterine adenomyosis to optimize their fertility potential.

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Outcome instruments

NRS-pain

Condition tags

adenomyosisdysmenorrheainfertility

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

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last seen: 2026-06-18T06:15:08.409253+00:00
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