Coagulation Status in Women With Endometriosis

Paola Viganò, Jessica Ottolina, Veronica Sarais, Giorgia Rebonato, Edgardo Somigliana, Massimo Candiani
Reproductive sciences (Thousand Oaks, Calif.) · 2017 · vol. 25(4) , pp. 559–565 · doi:10.1177/1933719117718273 · PMID:28681683 · W2735617250
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

Women with endometriosis showed a significantly shortened activated partial thromboplastin time compared to controls, which remained associated with the disease in logistic regression.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 · read from full text ⓘ

This cross-sectional surgical study evaluated coagulation-related variables and inflammatory markers in 314 women, comparing 169 patients with surgically diagnosed endometriosis (any stage) to 145 controls with surgically diagnosed benign gynecologic pathology. Most measured parameters were not different between groups, including thrombin time, INR, platelet count, neutrophils, lymphocytes, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio, while endometriosis patients had significantly shortened activated partial thromboplastin time (APTT) that remained within the normal range. Subgroup analyses showed shorter APTT particularly in ovarian endometriosis and in stage I–II disease, and multivariate logistic regression indicated shortened APTT stayed associated with endometriosis after adjusting for confounders. The authors conclude evidence is insufficient to use APTT as a diagnostic marker and that a systemic hypercoagulable state is not clearly established, with a possible contribution of local coagulation not excluded. This paper is centrally about endometriosis — it measures systemic coagulation status differences, finding shorter APTT in women with endometriosis.

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Abstract

Subtle alterations in coagulation and fibrinolysis have been recently reported in patients with endometriosis supporting a potential hypercoagulable status associated with the disease. This cross-sectional study aimed at evaluating some variables of coagulation status and inflammatory markers in women with endometriosis. A total of 314 women who underwent surgery were considered. The case group (n = 169) included patients with a surgical diagnosis of endometriosis, at any stage of disease. The control group (n = 145) included women with a surgical diagnosis of benign gynecologic pathology. No difference was found for thrombin time, International Normalized Ratio (INR), platelet count, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio, and platelet-to-lymphocyte ratio (PLR) between women with endometriosis and controls. Conversely, patients with endometriosis had significantly shortened activated partial thromboplastin time (APTT) when compared to controls (1.08 ± 0.06 and 1.12 ± 0.19, respectively; P <.01). In the subgroup analysis, women with ovarian endometriosis had significantly shortened APTT values in comparison to women without this form and women with stage I to II endometriosis had significantly shorter APTT values and higher PLR than those with stage III to IV disease. In multivariate logistic regression analysis, after controlling for potential confounders, a shortened APTT remained associated with the disease. Activated partial thromboplastin time is shorter in women with endometriosis but still in the normal range. The evidence is insufficient to foresee a possible use of APTT as a diagnostic marker and to claim a crucial role of a systemic hypercoagulable state in the origin of the disease. A role of the local coagulation system in the pathogenesis of the disease cannot be excluded. Similar content being viewed by others

References

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Blood Coagulation Blood Platelets Endometriosis Lymphocytes Ovarian Diseases Peritoneal Diseases Adult Blood Coagulation Blood Coagulation Tests Cross-Sectional Studies Endometriosis Female Humans Ovarian Diseases Partial Thromboplastin Time Peritoneal Diseases Prothrombin Time

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