ENDOMETRIOSIS AND VTE: A REVIEW OF THE EVIDENCE AND PATHOPHYSIOLOGICAL MECHANISMS

Julia Dura, Julia Ciechanowicz, Stanisław Ciechanowicz, Marika Gutowska, Piotr Kupidłowski, Agata Nowacka, Adrianna Perzanowska, Aleksandra Przybylska, Z Tomaszewska, Anna Zielińska
In: International Journal of Innovative Technologies in Social Science · 2025 · doi:10.31435/ijitss.3(47).2025.3489 · W4412568705
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review of seven studies suggests an elevated venous thromboembolism risk in women with endometriosis, potentially linked to inflammation and hormonal influences, though the association remains unclear.

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Abstract

Introduction and objective: Endometriosis is a chronic inflammatory condition affecting approximately 10% of women of reproductive age. Venous thromboembolism (VTE) is a major cause of mortality worldwide. Because the relationship between endometriosis and VTE is not well-defined, we conducted a review of studies that assessed the occurrence of VTE in women with endometriosis. Review methods: A structured PubMed search was conducted to identify studies published between January 2015 and April 2025 assessing the risk of VTE in patients with endometriosis. Seven studies met the inclusion criteria after screening for relevance and exclusion of case reports. Abbreviated description of the state of knowledge: Some large-scale studies suggest an elevated VTE risk in women with endometriosis, particularly in younger individuals, during pregnancy, or when using hormonal therapy. However, results vary due to differences in study design, diagnostic definitions, and confounder adjustment. Pathophysiologically, endometriosis-related inflammation, hormonal influences, and endothelial dysfunction may contribute to a prothrombotic state. Summary: The association between endometriosis and VTE remains unclear; biologically plausible mechanisms and clinical patterns suggest it may be relevant in certain populations. Future research should focus on well-characterized, prospective studies. Clinicians should remain alert to thrombotic risk in women with endometriosis, especially when additional risk factors are present.

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Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (33)

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