Basal and stimulated secretion of cytokines by peritoneal macrophages in women with endometriosis

Rana N, Nasir Rana, N Rana, Braun DP, Donald P. Braun, D P Braun, Robert V. House, R House, House R, Howard M. Gebel, Gebel H, H Gebel, C Rotman, Carlos Rotman, Rotman C, Dmowski WP, W. Paul Dmowski, W P Dmowski
Fertility and Sterility · 1996 · vol. 65(5) , pp. 925–930 · doi:10.1016/s0015-0282(16)58262-4 · PMID:8612850 · W98713221
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study investigated the levels of cytokines secreted by peritoneal macrophages from women with endometriosis under both basal and stimulated conditions.

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Abstract

ObjectiveTo evaluate basal (constitutive) and stimulated synthesis of tumor necrosis factor alpha (TNF alpha), interleukin (IL)-8, IL-10 by peritoneal macrophages (PM) in women with endometriosis.DesignPeritoneal macrophages were cultured in the presence or absence of lipopolysaccharide (LPS) for 24 hours. Peritoneal fluids (PF) and PM supernatants were assayed for cytokines using ELISA.SettingInstitute for the Study and Treatment of Endometriosis and university-based research laboratories.SubjectsFertile controls undergoing tubal ligation (n = 8) and women with endometriosis (n = 17).InterventionPeritoneal fluid samples were obtained at the time of diagnostic laparoscopy (endometriosis group) or laparoscopy for tubal ligation; both were performed in the midluteal phase of the cycle.ResultsBoth basal and LPS stimulated production of TNF alpha, IL-8, and IL-10 by the PM were elevated significantly in women with endometriosis as compared with the fertile controls.ConclusionsThis study demonstrated that cytokines TNF alpha, IL-8, and IL-10 are synthesized at greater than normal levels by basal and stimulated PM from women with endometriosis. The levels of TNF alpha and IL-8 correlated with the levels in the PF, suggesting that PM are the principal source of these cytokines in the PF.

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Condition tags

endometriosis

MeSH descriptors

Cytokines Endometriosis Lipopolysaccharides Macrophages, Peritoneal Ascitic Fluid Ascitic Fluid Cells, Cultured Cytokines Endometriosis Female Humans Interleukin-10 Interleukin-10 Interleukin-8 Interleukin-8 Lipopolysaccharides Macrophages, Peritoneal Tumor Necrosis Factor-alpha Tumor Necrosis Factor-alpha

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (27)

Cited by (50)

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