The link between inflammation and hemostasis in endometriosis: a call for research

Maíra Casalechi, Armando Tripodi, Fernando M. Reis, Giorgia Carullo, I Mondini, Giorgia Di Stefano, Maria Carla Palermo, Marco Reschini
In: Journal of Endometriosis and Uterine Disorders · 2023 · vol. 3 , pp. 100040 · doi:10.1016/j.jeud.2023.100040 · W4386002881
article OA: diamond CC0 ⤵ 6 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This paper reviews current evidence suggesting that subtle disturbances in the hemostasis system may be present in women with endometriosis and warrant further research.

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Abstract

Endometriosis, an inflammatory-hormonal chronic disease, has a strong impact on women's quality of life, and fertility; however, after decades of intensive investigation, the complex events underlying its development and progression remain elusive, and no specific and curative treatment is available yet. Recently, new evidence started to shed light to a biological system that might be related to endometriosis pathophysiology and that, so far, was outside our attention: the hemostasis system. This system works in a balanced way with inflammation, being their interaction so strict and complex that it is predictable that a disturbance in one contributes significantly to several alterations in the other. The link between hemostasis and inflammation is characteristic of some chronic inflammatory diseases, suggesting its possible role also in the development, and/or symptoms of endometriosis. In women with endometriosis, although hemostasis parameters seem to remain in the normal reference ranges, subtle alterations of the hemostasis profile were described. In this overview we discussed the current findings supporting the idea that women with endometriosis might be characterized by hemostasis disturbance and that these alterations may become evident if accurately evaluated.

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Condition tags

endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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