Endometriosis and Tissue Factor

Graciela Krikun, Frederick Schatz, Hugh S. Taylor, Hugh Taylor, Charles J Lockwood
Annals of the New York Academy of Sciences · 2008 · vol. 1127(1) , pp. 101–105 · doi:10.1196/annals.1434.008 · PMID:18443336 · W1968002494
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review discusses altered tissue factor expression in endometriosis, proposing it drives inflammation and macrophage recruitment via PAR-2 and suggests it as a therapeutic target.

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Abstract

Tissue factor (TF), is a cellular receptor that binds the ligand factor VII/VIIa to initiate the blood coagulation cascade. In addition to its role as the initiator of the hemostatic cascade, TF is known to be involved in angiogenesis via an interaction with factor VIIa and protease-activated receptor-2 (PAR-2). In this article we review previous studies from our laboratory demonstrating that the pattern and level of TF expression is altered in multiple cell types derived from eutopic and ectopic endometrium from women with endometriosis compared with normal endometrium. We posit that the inflammatory environment that occurs in ectopic and eutopic endometrium from patients with disease results in high TF expression that in turn, signals via PAR-2 to further produce inflammatory cytokine or chemokine production and macrophage recruitment. Thus, our studies suggest that TF might be an ideal target for therapeutic intervention in endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometrium Gene Expression Regulation Neovascularization, Pathologic Thromboplastin Animals Cell Proliferation Cytokines Cytokines Endometriosis Endometrium Female Humans Immunohistochemistry Immunohistochemistry Infertility, Female Infertility, Female Inflammation Mice

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (78)

Cited by (41)

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