Tissue factor expression and tumor‐infiltrating T lymphocytes in ovarian carcinomas and their association with venous thromboembolism

Toshihiro Gi, Atsushi Yamashita, Murasaki Aman, Aya Kuwahara, Yujiro Asada, Yasuyuki Kawagoe, Junji Onishi, Hiroshi Sameshima, Yuichiro Sato
Pathology international · 2021 · vol. 71(4) , pp. 261–266 · doi:10.1111/pin.13074 · PMID:33559251 · W3126499729
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This study found that higher tissue factor expression and CD8+ lymphocytes in ovarian carcinomas, particularly clear cell carcinoma, were associated with venous thromboembolism.

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Abstract

Ovarian cancer is a known risk factor of venous thromboembolism (VTE). Thrombogenic factor expression and lymphocytic infiltrate have been reported in endometriosis and ovarian cancers. We reviewed 30 cases of ovarian carcinomas (high grade serous carcinoma, 10; endometrioid carcinoma, 10; clear cell carcinoma (CCC), 10) and 16 endometriotic lesions. We immunohistochemically investigated the expressions of tissue factor (TF), podoplanin, P-selectin, and number of CD4 and CD8 positive lymphocytes in cancer tissue and endometriotic lesions, along with their relationship with VTE. The expression of TF was higher in CCC. The TF expression and the number of CD8 positive cells were higher in cancer tissues with VTE than in those without VTE. The podoplanin or P-selectin expression did not differ among histological types or between cases with and without VTE. Our results demonstrated a high TF expression and intraepithelial CD8 cells in CCC, which were associated with VTE. The results suggest that infiltrating lymphocytes may affect TF expression that, in turn, influences VTE.

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Condition tags

endometriosis

MeSH descriptors

Lymphocytes, Tumor-Infiltrating Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms Thromboplastin Venous Thromboembolism Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Adenocarcinoma, Clear Cell Aged Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid Carcinoma, Endometrioid CD8-Positive T-Lymphocytes CD8-Positive T-Lymphocytes Female Humans Lymphocytes, Tumor-Infiltrating

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Cites (2)

References (19)

Source provenance

europepmc
last seen: 2026-06-13T06:22:48.782012+00:00
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