Identification of Novel Putative Urinary Markers of Endometriosis by High-Resolution Quantitative Proteomics

Domenico Milardi
In: Biomedical Journal of Scientific & Technical Research · 2020 · vol. 28(2) · doi:10.26717/bjstr.2020.28.004628 · W3102812136
article OA: diamond CC0 ⤵ 3 in-corpus citations
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Abstract

Endometriosis is a chronic gynecological inflammatory disease characterized by the presence of functional endometrial glands and stroma outside of the uterine cavity. It is an estrogen-dependent disease affecting 7-10% of women of reproductive age. Laparoscopic diagnosis remains the gold standard approach, providing that the risks these minimally invasive surgical procedures are understood and accepted by the patients. The aim of this study was to compare urine proteomic profiles in patients with endometriosis versus controls, trying to identify a panel of specific proteins representing novel non-invasive biomarkers of endometriosis. Eight 30-40 years old women with laparoscopically verified ovarian endometriotic cysts were enrolled. Five fertile women with non-endometriotic ovarian cystsand no visual signs of peritoneal endometriosis served as control group. Morning urine were collected in the day of the scheduled surgery and processed to be analyzed by proteomic. Eleven proteins were increased in endometriosis, while prothrombin was reduced. Seven proteins were found to fall into one large protein-protein interaction network, mainly involved with inflammation. This is the first report on the application of quantitative proteomics in the search of an array of urinary proteins, which may guide further studies for the validation of novel non-invasive biomarkers of endometriosis.

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