Does exist a correlation between endometriosis and thrombophilic disorders? A pilot study

Roberto Paradisi, Giulia Ferrini, Carlotta Matteucci, Chiara Facchini, Letizia Zannoni, Renato Seracchioli
Taiwanese journal of obstetrics & gynecology · 2017 · vol. 56(3) , pp. 371–373 · doi:10.1016/j.tjog.2017.04.020 · PMID:28600052 · W2623478452
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This pilot study found a significantly reduced prevalence of Factor V Leiden mutation in endometriosis patients compared to controls, while Factor II and hyperhomocysteinemia showed no significant differences.

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Abstract

OBJECTIVE: At present, there is growing evidence of the existence of a genetic predisposition in both thrombophilic disorders and endometriosis. The aim of our study was to evaluate for the first time the prevalence of some thrombophilic disorders in patients with endometriosis. MATERIALS AND METHODS: We conducted a retrospective study on 138 patients with endometriosis and 278 healthy control women. All women were subjected to a blood examination testing for thrombophilic screening and the variables examinated were: hyperhomocysteinemia, factor V Leiden and factor II prothrombin G20210A mutations in heterozygosis and homozigosis. RESULTS: A significant reduced prevalence (p < 0.05) of factor V Leiden mutation in endometriosis patients was found, whereas no significant differences (p = NS) for factor II and hyperhomocysteinemia were observed. CONCLUSION: Our preliminary data do not show any association between thrombophilic condition and endometriosis. Before assuming hormonal therapies, a thrombophilic plasmatic screening seems to be unnecessary in patients affected by endometriosis.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Thrombophilia Adult Case-Control Studies Endometriosis Endometriosis Factor V Factor V Female Genetic Predisposition to Disease Humans Mass Screening Pilot Projects Retrospective Studies Thrombophilia Thrombophilia

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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