Does exist a correlation between endometriosis and thrombophilic disorders? A pilot study

Paradisi R, Roberto Paradisi, Giulia Ferrini, Ferrini G, Carlotta Matteucci, Matteucci C, Chiara Facchini, Facchini C, Zannoni L, Letizia Zannoni, Renato Seracchioli
Taiwanese journal of obstetrics & gynecology · 2017 · vol. 56(3) , pp. 371–373 · doi:10.1016/j.tjog.2017.04.020 · PMID:28600052 · W2623478452
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This pilot study found a significantly reduced prevalence of Factor V Leiden mutation in endometriosis patients compared to controls, while Factor II and hyperhomocysteinemia showed no significant differences.

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Abstract

OBJECTIVE: At present, there is growing evidence of the existence of a genetic predisposition in both thrombophilic disorders and endometriosis. The aim of our study was to evaluate for the first time the prevalence of some thrombophilic disorders in patients with endometriosis. MATERIALS AND METHODS: We conducted a retrospective study on 138 patients with endometriosis and 278 healthy control women. All women were subjected to a blood examination testing for thrombophilic screening and the variables examinated were: hyperhomocysteinemia, factor V Leiden and factor II prothrombin G20210A mutations in heterozygosis and homozigosis. RESULTS: A significant reduced prevalence (p < 0.05) of factor V Leiden mutation in endometriosis patients was found, whereas no significant differences (p = NS) for factor II and hyperhomocysteinemia were observed. CONCLUSION: Our preliminary data do not show any association between thrombophilic condition and endometriosis. Before assuming hormonal therapies, a thrombophilic plasmatic screening seems to be unnecessary in patients affected by endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Thrombophilia Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Factor V Factor V Factor V Female Female Genetic Predisposition to Disease Genetic Predisposition to Disease Humans Humans Mass Screening Mass Screening

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (19)

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