Systematic review and meta‐analysis of adverse pregnancy outcomes after uterine adenomyosis

Maryam Razavi, Arezoo Maleki-Hajiagha, Arezoo Maleki‐Hajiagha, Mahdi Sepidarkish, Safoura Rouholamin, Amir Almasi‐Hashiani, Amir Almasi-Hashiani, Mahroo Rezaeinejad
International Journal of Gynecology & Obstetrics · 2019 · vol. 145(2) , pp. 149–157 · doi:10.1002/ijgo.12799 · PMID:30828808 · W2918503691
review OA: closed CC0 ⤵ 40 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This meta-analysis of six studies found that women with adenomyosis have a higher likelihood of preterm birth, small for gestational age, and pre-eclampsia compared to women without adenomyosis.

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Abstract

BACKGROUND: Studies on the impact of adenomyosis and its pregnancy complications have yielded conflicting results. OBJECTIVE: To determine the likelihood of adverse pregnancy outcomes among women with adenomyosis relative to women without adenomyosis. SEARCH STRATEGY: PubMed, Embase, Scopus, and Web of Science were searched for studies published up to June 15, 2018. SELECTION CRITERIA: Observational studies with medically confirmed pregnancy outcomes as endpoints. DATA COLLECTION AND ANALYSIS: Two researchers independently screened and selected relevant studies. Dichotomous data for all adverse pregnancy outcomes were expressed as an odds ratio (OR) with 95% confidence interval (CI), and combined in a meta-analysis by using a random-effects model. MAIN RESULTS: Six studies (322 cases and 9420 controls) were eligible for inclusion in the meta-analysis. Women with adenomyosis had an increased likelihood of preterm birth (OR, 3.05; 95% CI, 2.08-4.47; P˂0.001), small for gestational age (OR, 3.22; 95% CI, 1.71-6.08; P˂0.001), and pre-eclampsia (OR, 4.35; 95% CI, 1.07-17.72; P=0.042). CONCLUSION: Adenomyosis seems to have a detrimental impact on pregnancy outcomes, resulting in a higher likelihood of preterm birth, small for gestational age, and pre-eclampsia.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Pre-Eclampsia Pregnancy Complications Premature Birth Adenomyosis Case-Control Studies Female Humans Infant, Newborn Infant, Small for Gestational Age Observational Studies as Topic Pre-Eclampsia Pregnancy Pregnancy Outcome Premature Birth

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

Cited by (40)

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