Premature Birth in Women with Endometriosis: a Systematic Review and Meta-analysis

Giovana Afférri Bonuccelli, Romulo Negrini, Rômulo Negrini, Raquel Domingues da Silva Ferreira
Reproductive sciences (Thousand Oaks, Calif.) · 2021 · vol. 29(1) , pp. 250–259 · doi:10.1007/s43032-021-00712-1 · PMID:34426947 · W3193649650
review OA: closed CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-10 ⓘ

This systematic review and meta-analysis of three studies found that women with endometriosis have an increased risk of premature birth compared to women without the diagnosis.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study conducted a systematic review and meta-analysis to assess whether endometriosis is associated with preterm birth by searching PubMed, Medline, and LILACS (up to April 2020) and adding manual searches of theses, guidelines, and reviews, including prospective cohort studies that reported preterm delivery prevalence among women with endometriosis, adenomyosis, or endometrioma compared with controls without these diagnoses. Three studies totaling 10,111 patients were included, and women with endometriosis had an increased risk of preterm birth (RR 2.68, 95% CI 1.19 to 6.02; I²=91%); in spontaneous conception, the pooled estimate was higher (RR 3.26, 95% CI 2.09 to 5.09; I²=0%). The authors note substantial heterogeneity in the overall analysis (I²=91%), which is a key limitation. This paper is centrally about endometriosis — it is a systematic review and meta-analysis evaluating premature/preterm birth risk in women with endometriosis (including adenomyosis/endometrioma in search inclusion).

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Premature Birth Endometriosis Female Humans Infant, Newborn Pregnancy Premature Birth

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (42)

Cited by (9)

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License: CC0 · commercial use OK