Women with endometriosis at first pregnancy have an increased risk of adverse obstetric outcome

Nathalie Conti, Gabriele Cevenini, Silvia Vannuccini, Cinzia Orlandini, Herbert Valensise, Maria Teresa Gervasi, Fabio Ghezzi, Mariarosaria Di Tommaso, Filiberto Maria Severi, Felice Petraglia
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2014 · vol. 28(15) , pp. 1795–1798 · doi:10.3109/14767058.2014.968843 · PMID:25262994 · W2163787225
article OA: closed CC0 ⤵ 68 in-corpus citations
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Primiparous women with endometriosis face higher risks of adverse obstetric outcomes including small for gestational age fetuses, gestational diabetes, and preterm birth compared to controls.

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Abstract

OBJECTIVE: To evaluate pregnancy, delivery and neonatal outcome in singleton primiparous versus multiparous women with/without endometriosis. METHODS: Multicentric, observational and cohort study on a group of Caucasian pregnant women (n = 2239) interviewed during their hospitalization for delivery in five Italian Gynecologic and Obstetric Units (Siena, Rome, Padua, Varese and Florence). RESULTS: Primiparous women with endometriosis (n = 219) showed significantly higher risk of small for gestational age fetuses (OR: 2.72, 95% CI 1.46-5.06), gestational diabetes (OR: 2.13, 95% CI 1.32-3.44), preterm premature rupture of membranes (OR: 2.93, 95% CI 1.24-6.87) and preterm birth (OR: 2.24, 95% CI 1.46-3.44), and were hospitalized for a longer period of time (p < 0.0001) comparing with control group (n = 1331). Multiparous women with endometriosis (n = 97) delivered significantly more often small for gestational age fetuses (OR: 2.93, 95% CI 1.28-6.67) than control group (n = 592). Newborns of primiparous women with endometriosis needed more frequently intensive care (p = 0.05) and were hospitalized for a longer period of time (p < 0.0001). CONCLUSIONS: Women with endometriosis at first pregnancy have an increased risk of impaired obstetric outcome, while a reduced number of complications occur in the successive gestation. Therefore, it is worthy for obstetricians to increase the surveillance in nulliparous women with endometriosis during pregnancy.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Pregnancy Complications Pregnancy Outcome Uterine Diseases Case-Control Studies Endometriosis Female Gestational Age Humans Incidence Infant, Newborn Male Multicenter Studies as Topic Parity Pregnancy Pregnancy Complications Pregnancy Outcome Premature Birth Premature Birth Risk Factors

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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