Systematic review and meta-analysis regarding the association of endometriosis and preeclampsia in women conceiving spontaneously or through assisted reproductive technology

Pérez-López FR, Faustino R Pérez-López, Faustino R. Pérez‐López, Julia Calvo-Latorre, Calvo-Latorre J, Julia Calvo‐Latorre, Vanesa Alonso‐Ventura, Vanesa Alonso-Ventura, Alonso-Ventura V, Juan Bueno-Notivol, Juan Bueno‐Notivol, Samuel J Martínez-Domínguez, Martínez-Domínguez SJ, Samuel J. Martínez‐Domínguez, Chedraui P, Peter Chedraui, Health Outcomes, Systematic Analyses (HOUSSAY) Project
Pregnancy hypertension · 2018 · vol. 14 , pp. 213–221 · doi:10.1016/j.preghy.2018.01.003 · PMID:29934014 · W2781969664
review OA: closed CC0 ⤵ 16 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This systematic review and meta-analysis examined the association between endometriosis and preeclampsia in women conceiving spontaneously or via assisted reproductive technology.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

ObjectiveTo investigate the association between endometriosis and preeclampsia and/or its severe forms (eclampsia and/or the hemolysis, elevated liver enzymes and low platelet count [HELLP] syndrome) in pregnancies conceived either spontaneously or by assisted reproductive technology (ART).Design and methodsSystematic review and meta-analysis of observational studies. Search in PubMed-Medline, Scopus, Web of Science, Cochrane Library, Clinicaltrials.gov, the UK Clinical Trials Gateway, and the Australian New Zealand Clinical Trials Registry was conducted from inception through 21 June 2017, without language restrictions. Primary outcome was preeclampsia and/or its severe forms (eclampsia and/or HELLP syndrome) in pregnant women. Random-effects models were used for meta-analyses. Endometriosis effect was estimated as odds ratio (OR) with 95% confidence interval (CI).ResultsA total of 9 cohort and 4 case-control studies were eligible for data analysis, including 39,816 pregnancies with endometriosis and 2,831,065 without. Women with endometriosis diagnosed through biopsy did not have a higher preeclampsia, eclampsia and HELLP syndrome risk as compared to those without (OR 1.01, 95% CI 0.56-1.82); this was found the same even if endometriosis was diagnosed using other procedures (OR 1.15, 95% CI 0.94-1.40). Preeclampsia, eclampsia and HELLP syndrome risk was also not increased in women with endometriosis conceiving spontaneously (OR 1.21; 95% CI 0.94-1.56) or through ART (OR 0.74; 95% CI 0.41-1.35).ConclusionThis meta-analysis evidences that endometriosis was not associated to a higher risk of preeclampsia and/or its severe forms in pregnancies either conceived spontaneously or through ART.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Pre-Eclampsia Case-Control Studies Cohort Studies Endometriosis Endometriosis Female Humans Observational Studies as Topic Pre-Eclampsia Pre-Eclampsia Pregnancy Registries Reproductive Techniques, Assisted Risk Factors

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (51)

Cited by (17)

Source provenance

europepmc
last seen: 2026-08-11T06:11:44.160905+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:19:43.094626+00:00
unpaywall
last seen: 2026-06-02T02:00:03.124865+00:00
License: CC0 · commercial use OK