A 12-year cohort study on adverse pregnancy outcomes in Eastern Townships of Canada: impact of endometriosis

Aziz Aris
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2013 · vol. 30(1) , pp. 34–37 · doi:10.3109/09513590.2013.848425 · PMID:24134807 · W1974821304
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This 12-year cohort study of 31,068 pregnancies in Canada found that endometriosis increased the incidence of fetal loss, including spontaneous abortion and stillbirth.

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Abstract

The aim of this study was to provide a temporal-spatial reference of adverse pregnancy outcomes (APO) and examine whether endometriosis promotes APO in the same population. Among the 31 068 women who had a pregnancy between 1997 and 2008 in Eastern Townships of Canada, 6749 (21.7%) had APO. These APO increased significantly with maternal age and over time (r(2 )= 0.522, p = 0.008); and were dominated by preterm birth (9.3%), pregnancy-induced hypertension (8.3%) including gestational hypertension (6.5%), low birth weight (6.3%), gestational diabetes (3.4%), pregnancy loss (2.2%) including spontaneous abortion (1.5%) and stillbirth (0.6%), intrauterine growth restriction (2.1%) and preeclampsia (1.8%). Among the 31 068 pregnancies, 784 (2.5%) had endometriosis and 183 (23.3%) had both endometriosis and APO. Endometriosis has been shown to increase the incidence of fetal loss (OR = 2.03; 95% CI = 1.42-2.90, p < 0.0001), including spontaneous abortion (OR = 1.89; 95% CI = 1.23-2.93, p = 0.005) and stillbirth (OR = 2.29; 95% CI = 1.24-5.22, p = 0.012). This study provides a temporal-spatial reference on APO, which is a valuable tool for monitoring, comparing and correcting. It is also the first study to highlight an impact of endometriosis on the incidence of spontaneous abortion and stillbirth.

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Condition tags

endometriosis

MeSH descriptors

Pregnancy Complications Pregnancy Outcome Adult Canada Canada Cohort Studies Endometriosis Endometriosis Endometriosis Female Humans Incidence Infant, Low Birth Weight Infant, Newborn Peritoneal Diseases Peritoneal Diseases Peritoneal Diseases Pregnancy Pregnancy Complications Pregnancy Outcome

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Cited by (45)

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