Association between preeclampsia and eclampsia in Black women with endometriosis: a scoping review

Calbeth Alaribe, Calbeth C Alaribe, Kimberly D Sapre, Kimberly Sapre, Sapre KD
BMC public health · 2026 · vol. 26(1) · doi:10.1186/s12889-026-27739-w · PMID:42174507 · PMC13295340 · W7162078908
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This scoping review found no eligible US-based studies examining the association between endometriosis and preeclampsia/eclampsia in Black women, highlighting a critical research gap.

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This scoping review examined peer-reviewed literature to determine if any studies address the association between endometriosis and preeclampsia or eclampsia specifically among Black women in the United States. The authors searched nine databases for US-based studies involving reproductive-aged Black women with laparoscopically confirmed endometriosis who experienced these hypertensive disorders of pregnancy. The review identified no eligible studies because existing research was either conducted outside the US or failed to provide race-stratified outcomes, highlighting a significant gap in current data. This paper is centrally about endometriosis, as it investigates the specific comorbidity of preeclampsia and eclampsia within this patient population while noting the lack of focused research on Black women.

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Abstract

BACKGROUND: Women with endometriosis are at increased risk of preeclampsia and eclampsia, leading causes of maternal mortality among Black women in the United States. Despite this, Black women are significantly underdiagnosed with endometriosis. This scoping review examines how peer-reviewed literature addresses the association between endometriosis and preeclampsia/eclampsia in Black women in the US. METHOD: A comprehensive literature search was conducted across nine databases and PROSPERO for original articles published from inception through March 2024. Eligible studies were required to be US-based, include reproductive-aged Black women (15-49 years) with laparoscopically confirmed endometriosis, and report outcomes of preeclampsia and/or eclampsia. RESULTS: The search identified 370 records; 19 full-text articles were reviewed. None met all inclusion criteria, primarily because most studies were conducted outside the US or lacked race-stratified outcomes. As a result, no eligible studies investigated the association between endometriosis and preeclampsia or eclampsia in Black women in the US. CONCLUSIONS: This review reveals a significant gap in research examining endometriosis in Black women and its association with adverse pregnancy outcomes, including preeclampsia and eclampsia. The findings emphasize the need for inclusive, race-conscious research to inform clinical care and reduce maternal health disparities.
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Abstract

Background Women with endometriosis are at increased risk of preeclampsia and eclampsia, leading causes of maternal mortality among Black women in the United States. Despite this, Black women are significantly underdiagnosed with endometriosis. This scoping review examines how peer-reviewed literature addresses the association between endometriosis and preeclampsia/eclampsia in Black women in the US.

Method

A comprehensive literature search was conducted across nine databases and PROSPERO for original articles published from inception through March 2024. Eligible studies were required to be US-based, include reproductive-aged Black women (15–49 years) with laparoscopically confirmed endometriosis, and report outcomes of preeclampsia and/or eclampsia.

Results

The search identified 370 records; 19 full-text articles were reviewed. None met all inclusion criteria, primarily because most studies were conducted outside the US or lacked race-stratified outcomes. As a result, no eligible studies investigated the association between endometriosis and preeclampsia or eclampsia in Black women in the US.

Conclusions

This review reveals a significant gap in research examining endometriosis in Black women and its association with adverse pregnancy outcomes, including preeclampsia and eclampsia. The findings emphasize the need for inclusive, race-conscious research to inform clinical care and reduce maternal health disparities. Similar content being viewed by others Abbreviations - US: - United States - EMRs: - Electronic Medical Records - EMM: - Effect Measure Modification

Acknowledgements

The main author would like to acknowledge Dr. Christine Nkemeh, MD, for her valuable insights during the early stages of manuscript development. Funding This scoping review was not funded by any public, commercial, or not-for-profit agency. Author information Authors and Affiliations Corresponding author Ethics declarations Ethics approval and consent to participate Not applicable. Consent for publication Not applicable. Competing interests The authors declare no competing interests. Additional information Publisher’s Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Supplementary Information Rights and permissions Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which permits any non-commercial use, sharing, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if you modified the licensed material. You do not have permission under this licence to share adapted material derived from this article or parts of it. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by-nc-nd/4.0/. About this article Cite this article Alaribe, C.C., Sapre, K.D. Association between preeclampsia and eclampsia in black women with endometriosis: a scoping review. BMC Public Health (2026). https://doi.org/10.1186/s12889-026-27739-w Received: Accepted: Published: DOI: https://doi.org/10.1186/s12889-026-27739-w

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Condition tags

endometriosis

MeSH descriptors

Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American Black or African American

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (61)

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