Endometriosis and pregnancy complications: a Danish cohort study

Maria Tølbøll Glavind, Glavind MT, Axel Forman, Arendt LH, Linn Håkonsen Arendt, Karsten Nielsen, Nielsen K, Tine Brink Henriksen
Fertility and sterility · 2016 · vol. 107(1) , pp. 160–166 · doi:10.1016/j.fertnstert.2016.09.020 · PMID:27743699 · W2530513291
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This Danish cohort study investigated the association between endometriosis and adverse pregnancy outcomes, identifying links to specific complications.

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Abstract

ObjectiveTo study the association between endometriosis and risk of pre-eclampsia, cesarean section, postpartum hemorrhage, preterm birth, and small for gestational age (SGA), in a large Danish birth cohort, while taking fertility treatment into account.DesignPopulation-based study.SettingNot applicable.Patient(s)A total population of 82,793 singleton pregnancies from the Aarhus Birth Cohort (1989 through 2013); 1,213 women had a diagnosis of endometriosis, affecting 1,719 pregnancies.Intervention(s)None.Main outcome measure(s)Pre-eclampsia, cesarean section, postpartum hemorrhage, preterm birth, and SGA.Result(s)Endometriosis was associated with an increased risk of preterm birth (adjusted odds ratio [AOR] 1.67, 95% confidence interval [CI] 1.37-2.05), with the risk being highest for very preterm birth (AOR 1.91, 95% CI 1.16-3.15). Compared with unaffected women, women with endometriosis also had an increased risk of pre-eclampsia (AOR 1.37, 95% CI 1.06-1.77) and cesarean section (AOR 1.83, 95% CI 1.60-2.09). Assisted reproductive technology did not explain these findings. No association was found between endometriosis and postpartum hemorrhage or SGA.Conclusion(s)Women with endometriosis were at increased risk of pre-eclampsia, preterm birth, and cesarean section, irrespective of use of assisted reproductive technology.

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Condition tags

endometriosis

MeSH descriptors

Cesarean Section Endometriosis Infant, Premature Infertility, Female Pre-Eclampsia Premature Birth Reproductive Techniques, Assisted Adolescent Adult Birth Weight Denmark Denmark Endometriosis Endometriosis Female Gestational Age Humans Infant, Small for Gestational Age Infertility, Female Infertility, Female

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