Short-term obstetrical and neonatal complications in women with endometriosis

Noa Leybovitz‐Haleluya, Gil Gutvirtz, Anastasia Bendet, Eyal Sheiner
In: Archives of Gynecology and Obstetrics · 2026 · doi:10.1007/s00404-026-08519-8 · W7170052981
Observational OA: gold CC0
🔓 Open OA copy Full text JSON View on OpenAlex View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-07-30 ⓘ

This study found endometriosis to be an independent risk factor for cesarean delivery among singleton pregnancies, with other obstetric and neonatal outcomes being comparable to those without endometriosis.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by qwen3.7-flash, 2026-08-21 · read from full text ⓘ

This retrospective cohort study analyzed 232,476 singleton deliveries to evaluate the impact of endometriosis on obstetric and neonatal outcomes. Initial univariate analysis indicated that women with endometriosis faced higher rates of preterm birth, low birth weight, and cesarean delivery, but these associations were largely confounded by maternal age and fertility treatments. After adjusting for these variables using generalized estimation equation models, endometriosis remained an independent risk factor specifically for cesarean delivery, while other perinatal complications showed no significant difference compared to controls. This paper is centrally about endometriosis — specifically examining its association with short-term obstetrical and neonatal complications following pregnancy.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

Abstract

Abstract Objective Endometriosis is a chronic gynecological condition that affects women in their reproductive age and could potentially lead to reproductive difficulties. Despite extensive research into the impact of endometriosis on fertility and reproductive health, its association with obstetric complications and short-term neonatal outcomes is still an area of limited understanding with conflicting evidence in published studies. We conducted this study to explore a potential effect of endometriosis on obstetric and neonatal outcomes. Methods A retrospective population-based cohort study was conducted comparing obstetric and perinatal complications in women with and without endometriosis. We evaluated all singleton deliveries that occurred between 1991 and 2021 at a tertiary medical center. Fetuses with chromosomal abnormalities or congenital malformations were excluded. Generalized estimation equation (GEE) models were used to control for maternal recurrence in the cohort and for confounding variables. Results During the study period, 232,476 deliveries met our inclusion criteria, 0.1% ( n = 224) of whom had documented endometriosis. In the univariate analysis, women with endometriosis were significantly older, had higher rates of infertility and diabetes mellitus, and were more likely to undergo cesarean delivery. They also had higher rates of preterm birth and low birthweight infants, whereas perinatal mortality rates were comparable between the groups. In the GEE models, after controlling for maternal age, gravidity, and fertility treatments, the association for most of the aforementioned variables was no longer statistically significant. However, women with endometriosis were found to have a significant independent higher risk for cesarean delivery (adjusted OR 2.14 (1.62—2.83, p < 0.001). Conclusion Among the obstetrical and perinatal complications investigated in this study, endometriosis was found to be an independent risk factor for cesarean delivery, while all other pregnancy outcomes were comparable to women without endometriosis.
Full text 3,869 characters · extracted from oa-html · 4 sections · click to expand

Abstract

Objective Endometriosis is a chronic gynecological condition that affects women in their reproductive age and could potentially lead to reproductive difficulties. Despite extensive research into the impact of endometriosis on fertility and reproductive health, its association with obstetric complications and short-term neonatal outcomes is still an area of limited understanding with conflicting evidence in published studies. We conducted this study to explore a potential effect of endometriosis on obstetric and neonatal outcomes.

Methods

A retrospective population-based cohort study was conducted comparing obstetric and perinatal complications in women with and without endometriosis. We evaluated all singleton deliveries that occurred between 1991 and 2021 at a tertiary medical center. Fetuses with chromosomal abnormalities or congenital malformations were excluded. Generalized estimation equation (GEE) models were used to control for maternal recurrence in the cohort and for confounding variables.

Results

During the study period, 232,476 deliveries met our inclusion criteria, 0.1% (n = 224) of whom had documented endometriosis. In the univariate analysis, women with endometriosis were significantly older, had higher rates of infertility and diabetes mellitus, and were more likely to undergo cesarean delivery. They also had higher rates of preterm birth and low birthweight infants, whereas perinatal mortality rates were comparable between the groups. In the GEE models, after controlling for maternal age, gravidity, and fertility treatments, the association for most of the aforementioned variables was no longer statistically significant. However, women with endometriosis were found to have a significant independent higher risk for cesarean delivery (adjusted OR 2.14 (1.62—2.83, p < 0.001).

Conclusion

Among the obstetrical and perinatal complications investigated in this study, endometriosis was found to be an independent risk factor for cesarean delivery, while all other pregnancy outcomes were comparable to women without endometriosis. Similar content being viewed by others Funding Open access funding provided by Ben-Gurion University. This study was not funded. Author information Authors and Affiliations Corresponding author Ethics declarations Conflict of interest There were no financial disclosures. Leybovitz-Haleluya Noa, MD wrote the first draft of the manuscript. No honorarium, grant, or other form of payment was given to anyone to produce the manuscript. Additional information Publisher's Note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. Rights and permissions Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. About this article Cite this article Leybovitz-Haleluya, N., Gutvirtz, G., Bendet, A. et al. Short-term obstetrical and neonatal complications in women with endometriosis. Arch Gynecol Obstet (2026). https://doi.org/10.1007/s00404-026-08519-8 Received: Accepted: Published: DOI: https://doi.org/10.1007/s00404-026-08519-8

Text is read by the "Ask this paper" AI Q&A widget below. Extraction quality varies by source — PMC NXML preserves structure cleanly, OA-HTML may include some navigation residue, and OA-PDF can have broken hyphenation. The publisher copy (via DOI) is the canonical version.

My notes (saved in your browser only)

⚙ Ask this paper AI returns verbatim quotes from the full text · source: oa-html ⓘ

Answers must be backed by verbatim quotes from this paper's full text. Hallucinated quotes are dropped automatically; if no verbatim passage answers the question, we say so. How this works

Citation neighborhood (no data yet)

We don't have any in-corpus citations linked to this paper yet. This is a recent paper (2026) — citers typically take a year or two to land, and the OpenAlex reference graph may still be filling in.

Source provenance

openalex
last seen: 2026-10-09T06:00:51.939507+00:00
License: CC0 · commercial use OK