Presence of endometriosis and chronic overlapping pain conditions negatively impacts the pain experience in women with chronic pelvic-abdominal pain: A cross-sectional survey

Emily J. Bartley, Meryl J Alappattu, Meryl Alappattu, Kelsey Manko, Hannah Lewis, Terrie Vasilopoulos, Georgine Lamvu
Women's health (London, England) · 2024 · vol. 20 , pp. 17455057241248017 · doi:10.1177/17455057241248017 · PMID:38682290 · PMC11057341 · W4396222663
article OA: gold CC0 ⤵ 10 in-corpus citations
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Women with endometriosis and chronic overlapping pain conditions report greater pelvic pain severity, interference, and impact compared to those without endometriosis.

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Abstract

BACKGROUND: Evidence of overlap between endometriosis and chronic pain conditions is emerging; however, little is known about how the pain experience differs based on the presence or absence of endometriosis. OBJECTIVES: In a sample of women reporting chronic pelvic-abdominal pain (CPP), the aim of this study was to characterize differences in pain symptomatology between women with and without endometriosis and to examine the influence of chronic overlapping pain conditions (COPCs) on pain among these two groups. DESIGN: This was a cross-sectional study, based on an online survey. METHODS: Participants (aged 18+ years) completed a survey collecting pain diagnoses and symptoms assessing pelvic pain severity, pain interference, and pain impact. Independent sample t-tests, chi-square, and multiple linear regression models were employed to analyze group differences in pain symptomatology and COPCs. RESULTS: Of the 525 respondents with CPP, 25% (n = 133) reported having endometriosis. Women with endometriosis were younger at the onset of pelvic pain, relative to women without endometriosis (p = 0.04). There were no differences in age, race, ethnicity, or duration of pelvic pain between women with and without endometriosis. Women with endometriosis reported higher pelvic pain severity (+0.8, 95% CI = 0.4-1.1), pain interference (+5.9, 95% CI = 2.4-9.3), and pain impact (+1.9, 95% CI = 0.8-2.9). Endometriosis was associated with a higher number of COPCs (p = 0.003), with 25% (n = 33) of women reporting ⩾3 overlapping pain conditions compared with 12% (n = 45) of those without endometriosis. Women with endometriosis had a higher frequency of fibromyalgia (p < 0.001), chronic fatigue syndrome (p < 0.001), and temporomandibular disorder (p = 0.001). The number of COPCs was associated with higher pain severity, interference, and impact, independently of endometriosis. CONCLUSION: Women with endometriosis experienced higher levels of pain-related burden and COPCs compared with those without endometriosis. Pain intensity, interference, and impact increased with a higher number of pain conditions regardless of endometriosis presence.

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Outcome instruments

NRS-pain

Condition tags

endometriosischronic_pelvic_pain

MeSH descriptors

Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Abdominal Pain Chronic Pain

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (51)

Cited by (10)

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